Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata2tm2Sho mutation
(0 available);
any
Gata2 mutation
(26 available)
|
|
|
mortality/aging
N |
• mice are born in normal Mendelian ratios
|
hematopoietic system
N |
• erythpropoiesis and megakaryopoiesis appear normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm4Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
Gata2tm2Sho mutation
(0 available);
any
Gata2 mutation
(26 available)
|
|
|
mortality/aging
|
• mice begin to die at late E10.5
|
hematopoietic system
N |
• despite disruptions in erythropoiesis and megakaryopoiesis, granulocytes and macrophages form normally
|
|
• erythropoeisis is arrested in maturation at a precursor stage
|
|
• no megakaryocyte colonies can be generated from yolk sac cells unlike when wild-type cells are cultured
|