All Phenotypes Snai1<tm1Grid> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Snai1^tm1Grid
targeted mutation 1, Tom Gridley
MGI:2183156

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snai1^tm1Grid/Snai1^tm1Grid	Not Specified	MGI:2449988
ht2	Snai1^tm1Grid/Snai1^tm2.1Grid	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	MGI:3618120
cn3	Meox2^tm1(cre)Sor/Meox2⁺ Snai1^tm1Grid/Snai1^tm2Grid	involves: 129S1/Sv * 129S4/SvJaeSor	MGI:3715229
cn4	Meox2^tm1(cre)Sor/Meox2⁺ Snai1^tm1Grid/Snai1^tm2Grid Snai2^tm2Grid/Snai2^tm2Grid	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:3715232
cn5	Snai1^tm1Grid/Snai1^tm2Grid H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3715215
cn6	Snai1^tm1Grid/Snai1^tm2Grid Snai2^tm2Grid/Snai2^tm2Grid H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3715216
cx7	Snai1^tm1Grid/Snai1⁺ Snai2^tm2Grid/Snai2^tm2Grid	involves: 129S1/Sv * C57BL/6	MGI:3715218

Allelic Composition	Snai1^tm1Grid/Snai1^tm1Grid
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1^tm1Grid mutation (0 available); any Snai1 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:72861 )

• by E8.5, homozygous mutant embryos are in the process of resorption

embryo

abnormal gastrulation ( J:72861 )

• at E7.5, homozygous mutant embryos show defects in gastrulation and in the epithelial-mesenchymal transition required for normal formation of the mesoderm cell layer

abnormal mesoderm development ( J:72861 )

• at E7.5, most mutant embryos exhibit cavities or lacunae in the mesoderm layer, and the mesoderm cells lining these lacunae retain the morphology of an ordered columnar epithelium instead of having the typical mesenchymal morphology of wild-type mesoderm cells

• mutant mesoderm displays an apical-basal polarity that is characteristic of an epithelial cell layer

• mutant mesoderm cells contain microvilli at the apical surface facing into the lacunae and display numerous electron-dense adhesive junctions between cells

• at E7.5, E-cadherin expression is abnormally retained in the mesoderm of mutant embryos, although at lower levels than those observed in embryonic ectoderm

embryonic growth retardation ( J:72861 )

• by E8.5, homozygous mutant embryos appear severely retarded relative to wild-type embryos

decreased embryo size ( J:72861 )

• at E7.5, homozygous mutant embryos are smaller than wild-type embryos

absent amnion ( J:72861 )

• although a posterior amniotic fold forms, no amnion is observed at E7.5

absent chorion ( J:72861 )

• no chorion is observed at E7.5

growth/size/body

embryonic growth retardation ( J:72861 )

• by E8.5, homozygous mutant embryos appear severely retarded relative to wild-type embryos

decreased embryo size ( J:72861 )

• at E7.5, homozygous mutant embryos are smaller than wild-type embryos

Allelic Composition	Snai1^tm1Grid/Snai1^tm2.1Grid
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1^tm1Grid mutation (0 available); any Snai1 mutation (9 available)
Snai1^tm2.1Grid mutation (1 available); any Snai1 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal mesoderm development ( J:105294 )

• embryos develop lacunae within the mesodermal wings, bounded by mesodermal cells exhibiting the morphology of a polarized, columnar epithelium

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Snai1^tm1Grid/Snai1^tm2Grid
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Snai1^tm1Grid mutation (0 available); any Snai1 mutation (9 available)
Snai1^tm2Grid mutation (1 available); any Snai1 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:111702 )

• embryos survive as late as E9.5 when death occurs due to severe vascular defects

embryo

increased allantois apoptosis ( J:111702 )

• numerous apoptotic cells are observed in the posterior bulge of allantois in mutant embryos at E8.5

abnormal direction of embryo turning ( J:111702 )

• at E9.5, 46% of mutant embryos show reversed axial rotation compared to no control embryos

abnormal primitive streak morphology ( J:111702 )

abnormal allantois morphology ( J:111702 )

• at E8.5, poorly formed allantois with failure to fuse dorsally with the chorion is observed; there is a prominent dorsal bulge extruding dorsally. close to primitive streak

cardiovascular system

abnormal cardiac outflow tract development ( J:111702 )

• at E9.5, some mutant embryos display reversed position of the atrioventricular canal and outflow tract

abnormal heart development ( J:111702 )

• in 23% of embryos at E9.5, there is a vertical heart tube with ambiguous looping direction

abnormal fetal atrioventricular canal morphology ( J:111702 )

• at E9.5, in some embryos canal is reversed with outflow tract

abnormal direction of heart looping ( J:111702 )

• in 40% of mutant embryos, heart looping is reversed, whereas 37% show normal looping and remainder are ambiguous

cellular

increased allantois apoptosis ( J:111702 )

• numerous apoptotic cells are observed in the posterior bulge of allantois in mutant embryos at E8.5

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Snai1^tm1Grid/Snai1^tm2Grid Snai2^tm2Grid/Snai2^tm2Grid
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:111702 )

open neural tube ( J:111702 )

• double mutants display an open neural tube at E9.5

growth/size/body

embryonic growth retardation ( J:111702 )

nervous system

nervous system phenotype ( J:111702 )

N	• in E8.5 cranial fold explants cultured for 48 hours, neural crest cell delamination and migration are observed, similar to control explants

open neural tube ( J:111702 )

• double mutants display an open neural tube at E9.5

Allelic Composition	Snai1^tm1Grid/Snai1^tm2Grid H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Snai1^tm1Grid mutation (0 available); any Snai1 mutation (9 available)
Snai1^tm2Grid mutation (1 available); any Snai1 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:121243 )

• animals are viable, fertile, and exhibit no phenotypic abnormalities

Allelic Composition	Snai1^tm1Grid/Snai1^tm2Grid Snai2^tm2Grid/Snai2^tm2Grid H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:121243 )

• resulting from cleft palate

craniofacial

abnormal Meckel's cartilage morphology ( J:121243 )

• the rostral portion of the Meckels cartilage is missing in neonates

frontal bone foramen ( J:121243 )

• enlarged frontal foramen in neonates

short parietal bone ( J:121243 )

• nenates have shortened parietal bones

short mandible ( J:121243 )

• mandible is shorter than in wild-type

domed cranium ( J:121243 )

• in neonates

abnormal palatal shelf morphology ( J:121243 )

• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5

cleft palate ( J:121243 )

• neonates show cleft palate

failure of palatal shelf elevation ( J:121243 )

• palatal shelves remain in a vertical growth orientation and fail to elevate

skeleton

abnormal Meckel's cartilage morphology ( J:121243 )

• the rostral portion of the Meckels cartilage is missing in neonates

frontal bone foramen ( J:121243 )

• enlarged frontal foramen in neonates

short parietal bone ( J:121243 )

• nenates have shortened parietal bones

short mandible ( J:121243 )

• mandible is shorter than in wild-type

domed cranium ( J:121243 )

• in neonates

digestive/alimentary system

abnormal palatal shelf morphology ( J:121243 )

• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5

cleft palate ( J:121243 )

• neonates show cleft palate

failure of palatal shelf elevation ( J:121243 )

• palatal shelves remain in a vertical growth orientation and fail to elevate

growth/size/body

abnormal palatal shelf morphology ( J:121243 )

• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5

cleft palate ( J:121243 )

• neonates show cleft palate

failure of palatal shelf elevation ( J:121243 )

• palatal shelves remain in a vertical growth orientation and fail to elevate

Allelic Composition	Snai1^tm1Grid/Snai1⁺ Snai2^tm2Grid/Snai2^tm2Grid
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1^tm1Grid mutation (0 available); any Snai1 mutation (9 available)
Snai2^tm2Grid mutation (1 available); any Snai2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:121243 )

craniofacial

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• dramatic reduction in apoptotic cells is observed at intersection of palatal shelves at E14.5

cleft palate ( J:121243 )

• penetrance is 100%

digestive/alimentary system

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• dramatic reduction in apoptotic cells is observed at intersection of palatal shelves at E14.5

cleft palate ( J:121243 )

• penetrance is 100%

growth/size/body

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• dramatic reduction in apoptotic cells is observed at intersection of palatal shelves at E14.5

cleft palate ( J:121243 )

• penetrance is 100%

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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