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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hrh1Bphs-r
B pertussis induced histamine sensitization, resistant
MGI:2182954
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hrh1Bphs-r/Hrh1Bphs-r C3H/HeJ MGI:5610128
ht2
Hrh1Bphs-r/Hrh1Bphs-s (C3H/HeJ x SJL/J)F1 MGI:5610127


Genotype
MGI:5610128
hm1
Allelic
Composition
Hrh1Bphs-r/Hrh1Bphs-r
Genetic
Background
C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrh1Bphs-r mutation (2 available); any Hrh1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice sensitized to Bordetella pertussis toxin (PTX) show no clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH) (J:4933)
(J:77938)




Genotype
MGI:5610127
ht2
Allelic
Composition
Hrh1Bphs-r/Hrh1Bphs-s
Genetic
Background
(C3H/HeJ x SJL/J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrh1Bphs-r mutation (2 available); any Hrh1 mutation (20 available)
Hrh1Bphs-s mutation (0 available); any Hrh1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice are susceptible to experimental allergic encephalomyelitis (EAE)
• males mice are susceptible to experimental allergic orchitis (EAO)
• hypersensitivity to agents and treatments that affect the vascular bed
• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)
• death due to experimental sensitivity occurred within 30 minutes

mortality/aging
• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)
• death due to experimental sensitivity occurred within 30 minutes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory