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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gpd2tm1Tka
targeted mutation 1, Takashi Kadowaki
MGI:2181289
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gpd2tm1Tka/Gpd2tm1Tka B6.Cg-Gpd2tm1Tka MGI:3852207
hm2
Gpd2tm1Tka/Gpd2tm1Tka involves: C57BL/6 * CBA MGI:3852185
cx3
Gpd2tm1Tka/Gpd2tm1Tka
Slc25a13tm1Lct/Slc25a13tm1Lct
B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct MGI:3852220


Genotype
MGI:3852207
hm1
Allelic
Composition
Gpd2tm1Tka/Gpd2tm1Tka
Genetic
Background
B6.Cg-Gpd2tm1Tka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpd2tm1Tka mutation (0 available); any Gpd2 mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• whether hypothyroid or euthyroid, cold challenge of mice adapted to 32 degrees Celsius produces a more prompt and marked hypothermia than in similarly treated wild-type mice
• at 22 degrees Celsius
• following injection with norepinephrine, mice exhibit increased brown adipose tissue and rectal temperatures compared with similarly treated wild-type mice
• about 7% less than wild-type mice at 22 and 30 degrees Celsius
• 17% less than wild-type mice at 32 degrees Celsius
• during acclimation to 32 degrees Celsius, T3 levels drop more than in wild-type mice
• at 22 and 32 degrees Celsius

growth/size/body
• about 5% due to small body size rather than altered body composition

adipose tissue
• at 22 degrees Celsius
• at 22 degrees Celsius, brown adipose fat droplets are smaller in size and greater in number than in similarly treated wild-type mice

behavior/neurological




Genotype
MGI:3852185
hm2
Allelic
Composition
Gpd2tm1Tka/Gpd2tm1Tka
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpd2tm1Tka mutation (0 available); any Gpd2 mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• glucose- or D-glyceraldehyde-stimulated insulin secretion in islet cells treated with AOA, an inhibitor of aspartate aminotransferase in the malate-aspartate shuttle, is abolished unlike in similarly treated wild-type cells
• the first phase of glucose-induced insulin secretion in islet cells treated with AOA is severely suppressed while the second phase is abolished unlike in similarly treated wild-type cells
• however, glibenclamide- or methyl pyruvate-induced insulin secretion in AOA treated islet cells is normal

growth/size/body
• 23% in males and 13% in females at 16 weeks

homeostasis/metabolism
• glucose- or D-glyceraldehyde-stimulated insulin secretion in islet cells treated with AOA, an inhibitor of aspartate aminotransferase in the malate-aspartate shuttle, is abolished unlike in similarly treated wild-type cells
• the first phase of glucose-induced insulin secretion in islet cells treated with AOA is severely suppressed while the second phase is abolished unlike in similarly treated wild-type cells
• however, glibenclamide- or methyl pyruvate-induced insulin secretion in AOA treated islet cells is normal




Genotype
MGI:3852220
cx3
Allelic
Composition
Gpd2tm1Tka/Gpd2tm1Tka
Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic
Background
B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpd2tm1Tka mutation (0 available); any Gpd2 mutation (75 available)
Slc25a13tm1Lct mutation (0 available); any Slc25a13 mutation (167 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 30% fewer than expected mice are found between 20 and 40 days

homeostasis/metabolism
• hepatic aspartic acid levels are higher than in wild-type mice
• citrulline and threonine/serine ratios are higher than in wild-type mice
• following oral sucrose administration, the plasma alanine concentration and branched amino acid/aromatic amino acid ratio are decreased compared to in wild-type mice
• under fed conditions and after oral sucrose administration
• plasma urea concentrations are higher than in wild-type mice
• compared to in wild-type mice and more severely than in Slc25a13tm1Lct homozygotes under fasting and fed conditions
• compared to wild-type mice and more severely than in Gpd2tm1Tka homozygotes

liver/biliary system
• following 16 hours of fasting

growth/size/body
• by 36 days in males and 29 days in females

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
citrullinemia DOID:9273 J:124766





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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory