Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Lira mutation
(0 available);
any
Ccr6 mutation
(36 available)
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immune system
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• lungs have 10-fold fewer peribronchial eosinophils after challenge with antigen to the airway compared to controls
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• there are 10-fold lower circulating IgE levels in mice that have had antigen challenge to their airways compared to challenged wild-type mice
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• mice have reduced airway hyperreactivity after antigen challenge
• airway resistance is 2-3 fold lower at its peak compared to controls
• decreased resistance compared to controls is seen up to 48 hours after antigen challenge
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• antigen challenged lungs secrete 5- to 8- fold less IL-5 compared to controls
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hematopoietic system
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• lungs have 10-fold fewer peribronchial eosinophils after challenge with antigen to the airway compared to controls
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• there are 10-fold lower circulating IgE levels in mice that have had antigen challenge to their airways compared to challenged wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Lira mutation
(0 available);
any
Ccr6 mutation
(36 available)
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immune system
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• transgenic T cells transferred into mutant mice fail to respond to bacteria
• transgenic T cells respond normally to soluble antigen derived from infecting bacteria
• T cells also respond to heat-killed bacteria
• T cell response to soluble antigen can be restored by transfusion of wild-type CD11b+ leukocyte phagocytes
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• S. typhimurium-specific T cells fail to expand in the Peyer's patch when transferred into mutant hosts that have been orally infected by bacteria
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• after S. typhimurium infection of the gut, dendritic cells fail to migrate and present antigen to T cells in the follicular associated epithelium in the small intestine
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hematopoietic system
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• transgenic T cells transferred into mutant mice fail to respond to bacteria
• transgenic T cells respond normally to soluble antigen derived from infecting bacteria
• T cells also respond to heat-killed bacteria
• T cell response to soluble antigen can be restored by transfusion of wild-type CD11b+ leukocyte phagocytes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Lira mutation
(0 available);
any
Ccr6 mutation
(36 available)
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immune system
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• myeloid dendritic cells are reduced by about half in the peritoneal cavity
• myeloid dendritic cells stay low during an inflammatory response to experimentally induced peritonitis
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• B1-B cell numbers are increased in the peritoneal cavity
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• numbers of B cells in the brain of unimmunized (i.e. no EAE) mice are about half that of wild-type controls
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• numbers of CD8 T cells in the brain of unimmunized (i.e. no EAE) mice are reduced compared to wild-type controls
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• alpha-beta IEL numbers in the small intestine are increased 2-fold
• CD69+ IEL are increased 6-fold, CD4+ IEL are increased 9 fold and CD4+CD8+ IEL are increased 10-fold
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• in addition to increased IEL numbers, lamina propia T cell numbers are also increased
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• CD4+CD8+ IEL are increased 10-fold in small intestine
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• CD69+ IEL are increased 6-fold in the small intestine
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• no Th17 T cells are detected in the CNS of mice with EAE while being readily found in wild-type mice with EAE
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• numbers of CD4 T cells in the brain of unimmunized (i.e. no EAE) mice are about half that of wild-type controls
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• peritoneal macrophage numbers are reduced by about a third
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• mice produce less rotavirus-specific IgA in response to infection compared to controls
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• mice produce significantly less total and antigen-specific levels of IgG3 in response to immunization
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• antigen-specific IgM levels are higher than controls after immunization
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• mutant Th17 T cells migrate slower across the blood-brain barrier than their wild-type counterparts in mixed bone marrow chimeras
• 7 days after transfer, 90% of transferred T cells in the brain are wild-type
• 16 days after transfer, proportions of wild-type T cells to knockout T cells are 60% vs 40%
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• peritoneal macrophage response to LPS is attenuated
• peritoneal macrophage response to LPS is enhanced when cells are isolated from mice with peritonitis
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• CCL2, CCL3, and CXCL10 production by peritoneal macrophages is attenuated in response to LPS
• KC, CCL2, CCL3, CXCL10 production is also reduced in mice undergoing peritonitis with lower levels detected in sera and peritoneal cavities
• peritoneal macrophage response to LPS is enhanced when cells are isolated from mice with peritonitis
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• NO production by peritoneal macrophages is attenuated in response to LPS or LPS+ IFN-gamma
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• in addition to increased IEL numbers, lamina propia T cell numbers are also increased
• after oral immunization, there are fewer antibody producing cells found in the lamina propia compared to controls
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• Peyer's patch lack the CD11b+ CD11c+ dendritic cell subset
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• after oral immunization, there are fewer antibody producing cells found in Peyer's patches compared to controls
• both IgA and IgG producing cells are affected and similar findings are seen whether KLH- or CT- specific antibody-producing cells are assayed
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• IL-10 production by peritoneal macrophages is attenuated in response to LPS
• IL-10 production is also reduced in mice undergoing peritonitis with lower levels detected in sera and peritoneal cavities
• peritoneal macrophage response to LPS is enhanced when cells are isolated from mice with peritonitis
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• IL-12p70 production by peritoneal macrophages is attenuated in response to LPS
• IL12-p70 production is also reduced in mice undergoing peritonitis with lower levels detected in sera and peritoneal cavities
• peritoneal macrophage response to LPS is enhanced when cells are isolated from mice with peritonitis
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• TNF production by peritoneal macrophages is attenuated in response to LPS
• TNF production is also reduced in mice undergoing peritonitis with lower levels detected in sera and peritoneal cavities
• peritoneal macrophage response to LPS is enhanced when cells are isolated from mice with peritonitis
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• are completely resistant to the development of MOG-induced EAE and do not show leukocyte infiltration in the CNS, whereas a few (8 of 26) have only minimal disease
• EAE can be induced when wild-type T cells are transfused into mutant recipient mice
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• mice have increased survival to experimental peritonitis induced by cecal ligation and puncture (CLP)
• 62% of mutant mice are alive six days after CLP while all of control mice are dead by 3 days
• antibiotic treatment reduces lethality for both groups but mutant mice still have a higher survival rate with 88% alive after 6 days compared 25% of wild-type mice
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• mice have delayed clearance of rotavirus
• mice have 2-fold higher virus in stools 5 to 6 days after infection compared to controls
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hematopoietic system
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• myeloid dendritic cells are reduced by about half in the peritoneal cavity
• myeloid dendritic cells stay low during an inflammatory response to experimentally induced peritonitis
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• B1-B cell numbers are increased in the peritoneal cavity
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• numbers of B cells in the brain of unimmunized (i.e. no EAE) mice are about half that of wild-type controls
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• numbers of CD8 T cells in the brain of unimmunized (i.e. no EAE) mice are reduced compared to wild-type controls
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• alpha-beta IEL numbers in the small intestine are increased 2-fold
• CD69+ IEL are increased 6-fold, CD4+ IEL are increased 9 fold and CD4+CD8+ IEL are increased 10-fold
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• in addition to increased IEL numbers, lamina propia T cell numbers are also increased
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• CD4+CD8+ IEL are increased 10-fold in small intestine
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• CD69+ IEL are increased 6-fold in the small intestine
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• no Th17 T cells are detected in the CNS of mice with EAE while being readily found in wild-type mice with EAE
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• numbers of CD4 T cells in the brain of unimmunized (i.e. no EAE) mice are about half that of wild-type controls
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• peritoneal macrophage numbers are reduced by about a third
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• mice produce less rotavirus-specific IgA in response to infection compared to controls
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• mice produce significantly less total and antigen-specific levels of IgG3 in response to immunization
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• antigen-specific IgM levels are higher than controls after immunization
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• mutant Th17 T cells migrate slower across the blood-brain barrier than their wild-type counterparts in mixed bone marrow chimeras
• 7 days after transfer, 90% of transferred T cells in the brain are wild-type
• 16 days after transfer, proportions of wild-type T cells to knockout T cells are 60% vs 40%
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• peritoneal macrophage response to LPS is attenuated
• peritoneal macrophage response to LPS is enhanced when cells are isolated from mice with peritonitis
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• CCL2, CCL3, and CXCL10 production by peritoneal macrophages is attenuated in response to LPS
• KC, CCL2, CCL3, CXCL10 production is also reduced in mice undergoing peritonitis with lower levels detected in sera and peritoneal cavities
• peritoneal macrophage response to LPS is enhanced when cells are isolated from mice with peritonitis
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• NO production by peritoneal macrophages is attenuated in response to LPS or LPS+ IFN-gamma
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nervous system
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• CD45+ cells accumulate in the choroid plexus parenchyma after MOG immunization
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homeostasis/metabolism
Analysis Tools