Ccr6^tm1Lira
Targeted Allele Detail

Summary

• Symbol: Ccr6^tm1Lira
• Name: C-C motif chemokine receptor 6; targeted mutation 1, Sergio A Lira
• MGI ID: MGI:2179552
• Synonyms: CCR6-, Ccr6⁰, D6^-
• Gene: Ccr6 Location: Chr17:8454875-8475973 bp, + strand Genetic Position: Chr17, 4.9 cM, cytoband A1
• Alliance: Ccr6^tm1Lira page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76461
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced most of the coding region. Northern analysis of spleen did not detect mRNA in homozygous mutant mice. Binding studies did not detect ligand on membranes prepared from spleens of homozygous mutant mice. (J:76461)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr6 Mutation: 36 strains or lines available

Notes

ES cell line strain of origin is given in J:76461 as "129 SvE."

References

• Original: J:76461 Cook DN, et al., CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity. 2000 May;12(5):495-503
• All: 27 reference(s)