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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mdktm1Tmu
targeted mutation 1, Takashi Muramatsu
MGI:2178959
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mdktm1Tmu/Mdktm1Tmu 129S2-Mdktm1Tmu MGI:3579531
hm2
Mdktm1Tmu/Mdktm1Tmu B6.129S2-Mdktm1Tmu MGI:3579532
cx3
Mdktm1Tmu/Mdktm1Tmu
Ptntm1Tmu/Ptntm1Tmu
involves: 129S2/SvPas * C57BL/6J MGI:3718113


Genotype
MGI:3579531
hm1
Allelic
Composition
Mdktm1Tmu/Mdktm1Tmu
Genetic
Background
129S2-Mdktm1Tmu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdktm1Tmu mutation (1 available); any Mdk mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• seen in 4 week old animals but not in 8 week old animals (J:76278)
• less time in the open on an elevated-plus maze (J:76278)
• increased defecation in an open field test (J:76278)
• seen in 4 week old animals but not in 8 week old animals (J:76278)
• less time in the open on an elevated-plus maze (J:76278)
• increased defecation in an open field test (J:76278)
• impaired short-term memory using a Y-shaped maze test at 4 weeks but not at 8 weeks (J:76278)
• impaired short-term memory using a Y-shaped maze test at 4 weeks but not at 8 weeks (J:76278)

nervous system
• delayed development of the hippocampus (J:60666)
• delayed development of the hippocampus (J:60666)
• retarded development (J:76278)
• retarded development (J:76278)

cardiovascular system
• suppressed on day 14 after carotid ligation (J:60666)
• few inflammatory leukocytes at points of intimal lesions (J:60666)
• lumen circumference significantly increased but not the external elastic lamina (J:60666)
• suppressed on day 14 after carotid ligation (J:60666)
• few inflammatory leukocytes at points of intimal lesions (J:60666)
• lumen circumference significantly increased but not the external elastic lamina (J:60666)

renal/urinary system
• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice (J:93637)
• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice (J:93637)
• less mortality from kidney failure after cisplatin administration- 90% survival to 7 days as opposed to 30% for controls (J:93637)
• fewer apoptotic cells (J:93637)
• indicators of kidney damage such as BUN, casts, tubular dilation and degeneration all higher than in controls (J:93637)
• fewer apoptotic cells (J:93637)
• less mortality from kidney failure after cisplatin administration- 90% survival to 7 days as opposed to 30% for controls (J:93637)
• indicators of kidney damage such as BUN, casts, tubular dilation and degeneration all higher than in controls (J:93637)

immune system
• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice (J:93637)
• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice (J:93637)




Genotype
MGI:3579532
hm2
Allelic
Composition
Mdktm1Tmu/Mdktm1Tmu
Genetic
Background
B6.129S2-Mdktm1Tmu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdktm1Tmu mutation (1 available); any Mdk mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased (J:102069)

behavior/neurological
N
• mice exhibit normal locomotor activity and acoustic startle reactivity (J:151029)
• mice exhibit normal locomotor activity and acoustic startle reactivity (J:151029)
• mice make less frequent contacts, longer times in total contacts, and longer times per one contact compared with wild-type mice (J:151029)
• mice make less frequent contacts, longer times in total contacts, and longer times per one contact compared with wild-type mice (J:151029)

nervous system
• in the striatum (J:151029)
• in the striatum (J:151029)
• adult mice exhibit reduced prepulse inhibition compared with wild-type mice (J:151029)
• however, prepubertal mice and mice treated with haloperidol or clozapine exhibit normal prepulse inhibition (J:151029)
• adult mice exhibit reduced prepulse inhibition compared with wild-type mice (J:151029)
• however, prepubertal mice and mice treated with haloperidol or clozapine exhibit normal prepulse inhibition (J:151029)

hearing/vestibular/ear
• mice experience low to moderate levels of auditory deficits (J:110520)
• mice experience low to moderate levels of auditory deficits (J:110520)

homeostasis/metabolism
• following partial hepatectomy (PH), amino-transferase levels are decreased (J:102069)
• following partial hepatectomy (PH), amino-transferase levels are decreased (J:102069)
• in the striatum (J:151029)
• in the striatum (J:151029)
• less severe adhesions of the intestine after partial hepatectomy (50% as opposed to 100%) (J:88890)
• omental adhesions reduced after peritoneal wall injury (J:88890)
• less severe adhesions of the intestine after partial hepatectomy (50% as opposed to 100%) (J:88890)
• omental adhesions reduced after peritoneal wall injury (J:88890)

liver/biliary system
• one day following partial hepatectomy (PH) (J:102069)
• one day following partial hepatectomy (PH) (J:102069)

hematopoietic system
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased (J:102069)

cellular
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased (J:102069)
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased (J:102069)

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:151029




Genotype
MGI:3718113
cx3
Allelic
Composition
Mdktm1Tmu/Mdktm1Tmu
Ptntm1Tmu/Ptntm1Tmu
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdktm1Tmu mutation (1 available); any Mdk mutation (39 available)
Ptntm1Tmu mutation (1 available); any Ptn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
(J:110520)
(J:110520)

hearing/vestibular/ear
• mice have a severe level of auditory defect (J:110520)
• mice do not respond to low frequency (8-12kHz) sounds and some mice respond to high frequency (16-20kHz) sounds (J:110520)
• however, no defects are observed in the cochlea (J:110520)
• mice have a severe level of auditory defect (J:110520)
• mice do not respond to low frequency (8-12kHz) sounds and some mice respond to high frequency (16-20kHz) sounds (J:110520)
• however, no defects are observed in the cochlea (J:110520)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory