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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mdktm1Tmu
targeted mutation 1, Takashi Muramatsu
MGI:2178959
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mdktm1Tmu/Mdktm1Tmu 129S2-Mdktm1Tmu MGI:3579531
hm2
Mdktm1Tmu/Mdktm1Tmu B6.129S2-Mdktm1Tmu MGI:3579532
cx3
Mdktm1Tmu/Mdktm1Tmu
Ptntm1Tmu/Ptntm1Tmu
involves: 129S2/SvPas * C57BL/6J MGI:3718113


Genotype
MGI:3579531
hm1
Allelic
Composition
Mdktm1Tmu/Mdktm1Tmu
Genetic
Background
129S2-Mdktm1Tmu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdktm1Tmu mutation (1 available); any Mdk mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• impaired short-term memory using a Y-shaped maze test at 4 weeks but not at 8 weeks
• seen in 4 week old animals but not in 8 week old animals
• less time in the open on an elevated-plus maze
• increased defecation in an open field test

nervous system
• delayed development of the hippocampus
• retarded development

cardiovascular system
• suppressed on day 14 after carotid ligation
• few inflammatory leukocytes at points of intimal lesions
• lumen circumference significantly increased but not the external elastic lamina

renal/urinary system
• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice
• less mortality from kidney failure after cisplatin administration- 90% survival to 7 days as opposed to 30% for controls
• fewer apoptotic cells
• indicators of kidney damage such as BUN, casts, tubular dilation and degeneration all higher than in controls

immune system
• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice




Genotype
MGI:3579532
hm2
Allelic
Composition
Mdktm1Tmu/Mdktm1Tmu
Genetic
Background
B6.129S2-Mdktm1Tmu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdktm1Tmu mutation (1 available); any Mdk mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

behavior/neurological
N
• mice exhibit normal locomotor activity and acoustic startle reactivity
• mice make less frequent contacts, longer times in total contacts, and longer times per one contact compared with wild-type mice

nervous system
• in the striatum
• adult mice exhibit reduced prepulse inhibition compared with wild-type mice
• however, prepubertal mice and mice treated with haloperidol or clozapine exhibit normal prepulse inhibition

hearing/vestibular/ear
• mice experience low to moderate levels of auditory deficits

homeostasis/metabolism
• following partial hepatectomy (PH), amino-transferase levels are decreased
• in the striatum
• less severe adhesions of the intestine after partial hepatectomy (50% as opposed to 100%)
• omental adhesions reduced after peritoneal wall injury

liver/biliary system
• one day following partial hepatectomy (PH)

hematopoietic system
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

cellular
• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased
• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:151029




Genotype
MGI:3718113
cx3
Allelic
Composition
Mdktm1Tmu/Mdktm1Tmu
Ptntm1Tmu/Ptntm1Tmu
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdktm1Tmu mutation (1 available); any Mdk mutation (39 available)
Ptntm1Tmu mutation (1 available); any Ptn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

hearing/vestibular/ear
• mice have a severe level of auditory defect
• mice do not respond to low frequency (8-12kHz) sounds and some mice respond to high frequency (16-20kHz) sounds
• however, no defects are observed in the cochlea





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory