Ptn^tm1Tmu
Targeted Allele Detail

Summary

• Symbol: Ptn^tm1Tmu
• Name: pleiotrophin; targeted mutation 1, Takashi Muramatsu
• MGI ID: MGI:3053747
• Synonyms: Ptn^-, PTN Tg2
• Gene: Ptn Location: Chr6:36691863-36787114 bp, - strand Genetic Position: Chr6, 15.48 cM
• Alliance: Ptn^tm1Tmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102069
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An MC1-neo cassette was inserted into the locus to replace a DNA segment through exon 3 to intron 3. Absence of transcript was confirmed by Northern blot of mutants. (J:102069, J:123392)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptn^tm1Tmu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptn Mutation: 14 strains or lines available

References

• Original: J:102069 Ochiai K, et al., The role of midkine and pleiotrophin in liver regeneration. Liver Int. 2004 Oct;24(5):484-91
• All: 12 reference(s)