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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcnj11tm1Sse
targeted mutation 1, Susumu Seino
MGI:2178821
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcnj11tm1Sse/Kcnj11tm1Sse B6.129P2-Kcnj11tm1Sse MGI:3619147
hm2
Kcnj11tm1Sse/Kcnj11tm1Sse involves: 129P2/OlaHsd MGI:3619152
hm3
Kcnj11tm1Sse/Kcnj11tm1Sse involves: 129P2/OlaHsd * C57BL/6 MGI:5432915
cx4
Kcnj11tm1Sse/Kcnj11+
Tg(Ins1-Kcnj11*)#Nich/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5432921
cx5
Kcnj11tm1Sse/Kcnj11tm1Sse
Tg(Ins1-Kcnj11*)#Nich/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5432923


Genotype
MGI:3619147
hm1
Allelic
Composition
Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic
Background
B6.129P2-Kcnj11tm1Sse
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj11tm1Sse mutation (1 available); any Kcnj11 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight is lower than controls after 20 weeks on a regular diet (J:157001)
• body weight is lower than controls after 20 weeks on a regular diet (J:157001)
• resistant to obesity on a high fat diet (J:157001)
• resistant to obesity on a high fat diet (J:157001)

homeostasis/metabolism
• reduced capacity relative to controls (J:157001)
• unable to sustain the same level of performance as controls for as long a period of time (J:157001)
• reduced capacity relative to controls (J:157001)
• unable to sustain the same level of performance as controls for as long a period of time (J:157001)
• after 60 minutes of volume expansion, the plasma ANF level in knockouts increases significantly, whereas in wild-type there is no change (J:106396)
• after 60 minutes of volume expansion, the plasma ANF level in knockouts increases significantly, whereas in wild-type there is no change (J:106396)
• higher rate of caloric output (J:157001)
• cumulative carbohydrate utilization in a 12 hour period is 4.5-5g/kg higher than in controls (J:157001)
• higher rate of caloric output (J:157001)
• cumulative carbohydrate utilization in a 12 hour period is 4.5-5g/kg higher than in controls (J:157001)
• resistant to obesity on a high fat diet (J:157001)
• resistant to obesity on a high fat diet (J:157001)
• higher oxygen consumption under sedentary conditions (J:157001)
• higher oxygen consumption under sedentary conditions (J:157001)
• significantly reduced although glucose secretion of isolated alpha-cells is normal (J:69163)
• injection of 2-deoxyglucose into the 3rd ventricle fails to stimulate glucagon secretion as it does in controls (J:69163)
• significantly reduced although glucose secretion of isolated alpha-cells is normal (J:69163)
• injection of 2-deoxyglucose into the 3rd ventricle fails to stimulate glucagon secretion as it does in controls (J:69163)
• severely impaired recovery from systemic hypoglycemia caused by insulin injection (J:69163)
• severely impaired recovery from systemic hypoglycemia caused by insulin injection (J:69163)

cardiovascular system
• after 60 minutes of volume expansion in knockouts, there is a significant increase in mean arterial pressure compared to wild-type (J:106396)
• after 60 minutes of volume expansion in knockouts, there is a significant increase in mean arterial pressure compared to wild-type (J:106396)

nervous system
• after 5 minutes of stretch, the action potential duration in the atria of knockouts remains unaltered but in wild-type it is shortened (J:106396)
• after 5 minutes of stretch, the action potential duration in the atria of knockouts remains unaltered but in wild-type it is shortened (J:106396)
• ventromedial hypothalamus neurons display higher discharge rates at low glucose levels which fail to increase at higher glucose levels (J:69163)
• ventromedial hypothalamus neurons display higher discharge rates at low glucose levels which fail to increase at higher glucose levels (J:69163)

behavior/neurological
• food intake is stimulated less by 2-deoxyglucose injection than is true in controls (J:69163)
• food intake is stimulated less by 2-deoxyglucose injection than is true in controls (J:69163)
• elevated intake of food at 3-4 months of age (J:157001)
• elevated intake of food at 3-4 months of age (J:157001)
• duration of voluntary activity is about half that of controls although the number of activity bouts is about the same (J:157001)
• duration of voluntary activity is about half that of controls although the number of activity bouts is about the same (J:157001)
• reduced capacity relative to controls (J:157001)
• unable to sustain the same level of performance as controls for as long a period of time (J:157001)
• reduced capacity relative to controls (J:157001)
• unable to sustain the same level of performance as controls for as long a period of time (J:157001)

adipose tissue
• depletion of subcutaneous fat deposits by 1 year of age (J:157001)
• depletion of subcutaneous fat deposits by 1 year of age (J:157001)
• depletion of abdominal fat deposits by 1 year of age (J:157001)
• depletion of abdominal fat deposits by 1 year of age (J:157001)

endocrine/exocrine glands
• significantly reduced although glucose secretion of isolated alpha-cells is normal (J:69163)
• injection of 2-deoxyglucose into the 3rd ventricle fails to stimulate glucagon secretion as it does in controls (J:69163)
• significantly reduced although glucose secretion of isolated alpha-cells is normal (J:69163)
• injection of 2-deoxyglucose into the 3rd ventricle fails to stimulate glucagon secretion as it does in controls (J:69163)

integument
• depletion of subcutaneous fat deposits by 1 year of age (J:157001)
• depletion of subcutaneous fat deposits by 1 year of age (J:157001)

pigmentation
N
• authors note that mutant mice are white rather than non-agouti black as expected on this congenic background and suggest that the non-B6 coat colors Oct2p and/or Tyrc-ch were inherited from the ESCell line used to generate the targeted allele Kcnj11tm1Sse (J:157001)
• authors note that mutant mice are white rather than non-agouti black as expected on this congenic background and suggest that the non-B6 coat colors Oct2p and/or Tyrc-ch were inherited from the ESCell line used to generate the targeted allele Kcnj11tm1Sse (J:157001)




Genotype
MGI:3619152
hm2
Allelic
Composition
Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj11tm1Sse mutation (1 available); any Kcnj11 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in response to elevated glucose levels or glucose and tolbutamide, insulin secretion by mutant beta cells is impaired compared to wild-type beta cells (J:49755)
• in response to elevated glucose levels or glucose and tolbutamide, insulin secretion by mutant beta cells is impaired compared to wild-type beta cells (J:49755)
• glucose tolerance in homozygous knockouts is slightly impaired compared to wild-type (J:49755)
• glucose tolerance in homozygous knockouts is slightly impaired compared to wild-type (J:49755)
• imutants injected with low doses of insulin display a significant lowering of blood glucose levels compared to wild-type (J:49755)
• imutants injected with low doses of insulin display a significant lowering of blood glucose levels compared to wild-type (J:49755)

nervous system
• myoclonic jerk in response to 150 seconds of hypoxia (J:69832)
• myoclonic jerk in response to 150 seconds of hypoxia (J:69832)
• severe tonic-clonic convulsion and death after hypoxia induced myoclonic jerk (J:69832)
• severe tonic-clonic convulsion and death after hypoxia induced myoclonic jerk (J:69832)
• firing rate of substantia nigra pars reticulata neurons increases about 1.8 fold during hypoxia rather than decreasing as it does in controls (J:69832)
• firing rate of substantia nigra pars reticulata neurons increases about 1.8 fold during hypoxia rather than decreasing as it does in controls (J:69832)
• substantia nigra pars reticulata neurons depolarize rather than hyperpolarize in hypoxic media (J:69832)
• substantia nigra pars reticulata neurons depolarize rather than hyperpolarize in hypoxic media (J:69832)

muscle
• myoclonic jerk in response to 150 seconds of hypoxia (J:69832)
• myoclonic jerk in response to 150 seconds of hypoxia (J:69832)
• tetanic force and maximum rate of force development reduced by 24-40% compared to younger mice as to a 7-17% reduction in controls (J:105244)
• tetanic force and maximum rate of force development is 21-23% less than in control mice (J:105244)
• recovery of tetanic force in 1 year old mice is considerable less than for controls (J:105244)
• tetanic force and maximum rate of force development reduced by 24-40% compared to younger mice as to a 7-17% reduction in controls (J:105244)
• tetanic force and maximum rate of force development is 21-23% less than in control mice (J:105244)
• recovery of tetanic force in 1 year old mice is considerable less than for controls (J:105244)
• mean peak tetanic force in the flexor digitorum brevis is significantly less than for controls (J:140833)
• peak total tetanic force drops faster than in controls for 30 seconds but then is significantly greater than in controls (J:140833)
• peak tetanic force recovery after fatigue is significantly slower than in controls (J:140833)
• mean peak tetanic force in the flexor digitorum brevis is significantly less than for controls (J:140833)
• peak total tetanic force drops faster than in controls for 30 seconds but then is significantly greater than in controls (J:140833)
• peak tetanic force recovery after fatigue is significantly slower than in controls (J:140833)
• half relaxation times are similar at 1 year and at 2-3 months whereas these times are considerably slower in 1 year old controls than in 2-3 month old controls (J:105244)
• resting tensions of extensor digitorum longus muscle from 2-3 month old mice are 5.6% of prefatigue tetanic force compared to 1.6-2.2% for controls (J:105244)
• resting tensions of 1 year old mice are 8.7% of prefatigue tetanic force (J:105244)
• half relaxation times are similar at 1 year and at 2-3 months whereas these times are considerably slower in 1 year old controls than in 2-3 month old controls (J:105244)
• resting tensions of extensor digitorum longus muscle from 2-3 month old mice are 5.6% of prefatigue tetanic force compared to 1.6-2.2% for controls (J:105244)
• resting tensions of 1 year old mice are 8.7% of prefatigue tetanic force (J:105244)
• peak tetanic force during fatigue initially drops faster than in controls although it is similar to controls after 90 seconds (J:140833)
• peak tetanic force during fatigue initially drops faster than in controls although it is similar to controls after 90 seconds (J:140833)

mortality/aging
• severe tonic-clonic convulsion and death after hypoxia induced myoclonic jerk (J:69832)
• severe tonic-clonic convulsion and death after hypoxia induced myoclonic jerk (J:69832)

behavior/neurological
• myoclonic jerk in response to 150 seconds of hypoxia (J:69832)
• myoclonic jerk in response to 150 seconds of hypoxia (J:69832)
• severe tonic-clonic convulsion and death after hypoxia induced myoclonic jerk (J:69832)
• severe tonic-clonic convulsion and death after hypoxia induced myoclonic jerk (J:69832)




Genotype
MGI:5432915
hm3
Allelic
Composition
Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj11tm1Sse mutation (1 available); any Kcnj11 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• spend more time on open and less in closed arms of an elevated plus maze than do controls (J:112822)
• spend more time on open and less in closed arms of an elevated plus maze than do controls (J:112822)
• spend most or all of their time in the fully enclosed alley of a successive alley test (J:112822)
• males but not females are considerably slower to drink in a hyponeophagia test than controls (J:112822)
• hyponeophagia results for males are reversed in a second test (J:112822)
• spend most or all of their time in the fully enclosed alley of a successive alley test (J:112822)
• males but not females are considerably slower to drink in a hyponeophagia test than controls (J:112822)
• hyponeophagia results for males are reversed in a second test (J:112822)
• females are less active than controls in spontaneous exploration tests (J:112822)
• females are less active than controls in spontaneous exploration tests (J:112822)
• lower rate of alternation in a spontaneous alternation test (J:112822)
• lower rate of alternation in a spontaneous alternation test (J:112822)
• markedly impaired performance on a static rod test (J:112822)
• slower to reorient themselves and move to safety (J:112822)
• more likely to fall off the rod (J:112822)
• normal rotarod performance (J:112822)
• slight impairment of performance on a horizontal bar test (J:112822)
• markedly impaired performance on a static rod test (J:112822)
• slower to reorient themselves and move to safety (J:112822)
• more likely to fall off the rod (J:112822)
• normal rotarod performance (J:112822)
• slight impairment of performance on a horizontal bar test (J:112822)
• significantly more home cage activity than controls (J:112822)
• less active than controls in open field tests, fewer squares crossed (J:112822)
• significantly more home cage activity than controls (J:112822)
• less active than controls in open field tests, fewer squares crossed (J:112822)
• less rearing and longer latency to first rearing (J:112822)
• less rearing and longer latency to first rearing (J:112822)




Genotype
MGI:5432921
cx4
Allelic
Composition
Kcnj11tm1Sse/Kcnj11+
Tg(Ins1-Kcnj11*)#Nich/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj11tm1Sse mutation (1 available); any Kcnj11 mutation (7 available)
Tg(Ins1-Kcnj11*)#Nich mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• reduced glucose stimulated insulin on a high fat diet (J:94610)
• reduced glucose stimulated insulin on a high fat diet (J:94610)
• elevated glucose stimulated insulin secretion at 4 months of age (J:94610)
• elevated glucose stimulated insulin secretion at 4 months of age (J:94610)
• higher blood glucose on a high fat diet (J:94610)
• higher blood glucose on a high fat diet (J:94610)
• elevated plasma insulin relative to controls on a normal diet but not on a high fat diet (J:94610)
• elevated plasma insulin relative to controls on a normal diet but not on a high fat diet (J:94610)
• glucose intolerant on a high fat diet (J:94610)
• glucose intolerant on a high fat diet (J:94610)
• enhanced glucose tolerance at 4 months of age (J:94610)
• enhanced glucose tolerance at 4 months of age (J:94610)

endocrine/exocrine glands
• higher insulin content in islets on a normal diet (J:94610)
• normal insulin content in islets on a high fat diet (J:94610)
• higher insulin content in islets on a normal diet (J:94610)
• normal insulin content in islets on a high fat diet (J:94610)
• reduced glucose stimulated insulin on a high fat diet (J:94610)
• reduced glucose stimulated insulin on a high fat diet (J:94610)
• elevated glucose stimulated insulin secretion at 4 months of age (J:94610)
• elevated glucose stimulated insulin secretion at 4 months of age (J:94610)




Genotype
MGI:5432923
cx5
Allelic
Composition
Kcnj11tm1Sse/Kcnj11tm1Sse
Tg(Ins1-Kcnj11*)#Nich/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj11tm1Sse mutation (1 available); any Kcnj11 mutation (7 available)
Tg(Ins1-Kcnj11*)#Nich mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• plasma insulin is not elevated on a high fat diet (J:94610)
• plasma insulin is not elevated on a high fat diet (J:94610)
• reduced baseline insulin secretion but normal plasma insulin (J:94610)
• reduced baseline insulin secretion but normal plasma insulin (J:94610)
• on a normal diet (J:94610)
• significantly increased blood glucose on a high fat diet relative to controls (J:94610)
• on a normal diet (J:94610)
• significantly increased blood glucose on a high fat diet relative to controls (J:94610)
• decreased glucose tolerance on both normal and high fat diet (J:94610)
• decreased glucose tolerance on both normal and high fat diet (J:94610)

endocrine/exocrine glands
• reduced baseline insulin secretion but normal plasma insulin (J:94610)
• reduced baseline insulin secretion but normal plasma insulin (J:94610)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory