Kcnj11^tm1Sse
Targeted Allele Detail

Summary

• Symbol: Kcnj11^tm1Sse
• Name: potassium inwardly rectifying channel, subfamily J, member 11; targeted mutation 1, Susumu Seino
• MGI ID: MGI:2178821
• Synonyms: Kir6.2-, Kir6.2KO, Kir6.2-KO
• Gene: Kcnj11 Location: Chr7:45746545-45750215 bp, - strand Genetic Position: Chr7, 29.66 cM
• Alliance: Kcnj11^tm1Sse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49755
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An exon of this gene was disrupted by the insertion of a neomycin gene via homologous recombination. No transcripts were detected in the tissues of homozygous mutant animals by RT-PCR analysis. Pancreatic beta cells of homozygous mutant animals did not exhibit membrane current activity as determined by whole cell assays. (J:49755)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnj11 Mutation: 31 strains or lines available

References

• Original: J:49755 Miki T, et al., Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10402-6
• All: 76 reference(s)