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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tlr2tm1Aki
targeted mutation 1, Shizuo Akira
MGI:2178675
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tlr2tm1Aki/Tlr2tm1Aki B6.129P2-Tlr2tm1Aki MGI:3696116
hm2
Tlr2tm1Aki/Tlr2tm1Aki C.129P2-Tlr2tm1Aki MGI:5297117
hm3
Tlr2tm1Aki/Tlr2tm1Aki involves: 129P2/OlaHsd MGI:3698170
hm4
Tlr2tm1Aki/Tlr2tm1Aki involves: 129P2/OlaHsd * C57BL/6 MGI:2178678
hm5
Tlr2tm1Aki/Tlr2tm1Aki NOD.129P2-Tlr2tm1Aki MGI:4942396
cx6
Tlr2tm1Aki/Tlr2tm1Aki
Tlr4tm1Aki/Tlr4tm1Aki
B6.129P2-Tlr2tm1Aki Tlr4tm1Aki MGI:3625114
cx7
Tlr2tm1Aki/Tlr2tm1Aki
Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd * C57BL/6 MGI:3707238
cx8
Tlr2tm1Aki/Tlr2tm1Aki
Tlr6tm1Aki/Tlr6tm1Aki
involves: 129P2/OlaHsd * C57BL/6 MGI:4456174


Genotype
MGI:3696116
hm1
Allelic
Composition
Tlr2tm1Aki/Tlr2tm1Aki
Genetic
Background
B6.129P2-Tlr2tm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal behavior in elevated zero maze and open field assays
• at 4-4.5 months of age, mice exhibit light cycle less movement, feeding and drinking compared with wild-type C57BL/6 mice and spend less time doing these activities
• at 4-4.5 months of age, mice exhibit increased state stability with fewer transitions between active and inactive states throughout the circadian day compared with wild-type C57BL/6
• at 4-4.5 months of age, mice exhibit fewer transitions between active/inactive states during the circadian light cycle compared with wild-type C57BL/6 mice
• at 4-4.5 months of age but less so at 8-8.5 months, mice exhibit less variability in circadian patterns of movement, feeding and drinking compared with wild-type C57BL/6 mice
• however, behavioral differences arent observed at 8-8.5 months of age
• reduced light cycle movement at 4-4.5 months of age
• mice exhibit fewer daily active/inactive states, lower active/inactive state transitions but longer active/inactive state durations compared with wild-type C57BL/6 mice
• however, behavioral differences arent observed at 8-8.5 months of age

immune system
• following infection with attenuated yellow fever vaccine 17D (YF-17D), the frequency of CD8+IFN-gamma+ T cells at day 10 is increased to 3.63% compared to 1.05% in wild-type mice
• Il-4 and IL-5 levels are increased
• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 and IL-6 relative to wild-type mice
• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 and IL-6 relative to wild-type mice
• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 and IL-6 relative to wild-type mice
• resistant to cerebral malaria
• reduced accumulation of hemozoin

hematopoietic system
• following infection with attenuated yellow fever vaccine 17D (YF-17D), the frequency of CD8+IFN-gamma+ T cells at day 10 is increased to 3.63% compared to 1.05% in wild-type mice

homeostasis/metabolism
N
• mice exhibit normal metabolic parameters
• fasting serum triglycerides are reduced on a high fat diet
• serum cholesterol levels at 5 weeks on a high fat diet are similar to controls
• levels do not increase on a high fat diet
• slightly elevated regardless of diet
• fasting serum glucose is not elevated at 14 weeks on a high fat diet as it is in controls
• serum insulin levels remain normal at 14 weeks on a high fat diet
• Il-4 and IL-5 levels are increased
• considerably reduced infarct volume after 1 hour of cerebral ischemia and 2 days of reperfusion
• reduced granulocyte chemotactic keratinocyte chemoattractant and monocyte chemoattractant protein-1 in kidneys 1 day after ischemia/reperfusion injury relative to controls
• fewer interstitial infiltrated granulocytes relative to controls at 1 day after injury but not at 5 and 10 days
• macrophage infiltration of the outer medulla peaks at 5 days
• less apoptosis of kidney tubular endothelial cells than in controls after injury
• less regeneration after injury than in controls after reperfusion injury

respiratory system
• Mycoplasma pneumoniae infection fails to induce mucin protein production in airways as occurs in controls (J:98456)
• bronchoalveolar protein levels are increased by ozone exposure (J:147534)
• ozone induced increase in bronchoalveolar cell counts is less than in controls at 3 hours but not 24 hours (J:147534)
• ozone exposure does not lead to hyperresponsiveness

neoplasm
• fewer liver tumors after injection with Lewis lung carcinoma cells
• fewer and smaller tumor nodules develop in the lung after injection with Lewis lung carcinoma cells

renal/urinary system
• reduced granulocyte chemotactic keratinocyte chemoattractant and monocyte chemoattractant protein-1 in kidneys 1 day after ischemia/reperfusion injury relative to controls
• fewer interstitial infiltrated granulocytes relative to controls at 1 day after injury but not at 5 and 10 days
• macrophage infiltration of the outer medulla peaks at 5 days
• less apoptosis of kidney tubular endothelial cells than in controls after injury
• less regeneration after injury than in controls after reperfusion injury

nervous system
• reduced differentiation of progenitor cells into neurons
• considerably reduced infarct volume after 1 hour of cerebral ischemia and 2 days of reperfusion
• differentiation of progenitor cells into astrocytes is improved

endocrine/exocrine glands
• beta cell volume as a percentage of pancreas volume is significantly reduced
• islet size is reduced
• number of islets is normal

adipose tissue
• do not develop increased adiposity on a high fat diet
• more moderate in size and with fewer associated leukocytes

growth/size/body
N
• lean body mass on a high fat diet is similar to controls
• do not develop increased adiposity on a high fat diet
• at 4-4.5 and 8-8.5 months of age
• however, mice exhibit normal bone mineral density, bone mineral content, bone area, ratio of soft tissue attenuation, and percent adiposity

liver/biliary system
• resistant to hepatosteatosis
• fewer liver tumors after injection with Lewis lung carcinoma cells

cellular
• reduced differentiation of progenitor cells into neurons




Genotype
MGI:5297117
hm2
Allelic
Composition
Tlr2tm1Aki/Tlr2tm1Aki
Genetic
Background
C.129P2-Tlr2tm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice treated with peptidoglycan or muramyl dipeptide (MDP) develop arthritis with the same severity and incidence as in similarly treated wild-type mice




Genotype
MGI:3698170
hm3
Allelic
Composition
Tlr2tm1Aki/Tlr2tm1Aki
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Pam3Cys-treated mice exhibit reduced Ly6Chi monocyte emigration from the bone marrow compared with similarly treated wild-type mice
• macrophages are unresponsive to macrophage activating lipopeptide 2 kD (MALP-2) and tripalitoyl cysteinyl lipopeptide (Pam3CSK4) (J:70578)
• response of macrophages to synthetic analogs of B. burgdorferi and T. pallidum lipopeptides is completely abrogated (J:70578)
• normal response of macrophages to lipopeptides of other bacterial origins (J:70578)
• activation by peptidoglycan, zymosan, and propionibacterium acnes fails (J:103464)
• reduced production of TNF alpha in response to Porphyromonas gingivalis (J:130138)
• cultural supernatant from P gingivalis stimulated peritoneal macrophage fails to stimulate osteoclast formation
• reduced after both 30 and 60 minutes of reperfusion following ventricular ischemia
• reduced after 30 but not 60 minutes of reperfusion following ventricular ischemia
• cytokine production by macrophages in response to both diacylated (macrophage activating lipopeptide 2 kD [MALP-2]) and triacylated lipopeptides (tripalitoyl cysteinyl lipopeptide [Pam3CSK4]), and synthetic analogs of B. burgdorferi and T. pallidum lipopeptides) is completely abrogated
• macrophages produce no NO and IL-12 in response to MALP-2 together with IFN-gamma or to Pam3CSK4
• MEFs treated with MALP-2 or Pam3CSK4 fail to produce IL-6
• macrophages produce no TNF-alpha in response to MALP-2 or Pam3CSK4 (J:70578)
• macrophages show impaired TNF-alpha production in response to heat-killed mycoplasma (J:70578)
• macrophages show no TNF-alpha production in response to the native mycobacterial 19-kDa lipoprotein and a synthetic triacylated lipopeptide, but respond normally to diacylated lipoprotein (J:103395)
• leukocyte influx into cerebrospinal fluid occurs but is less than in controls after S. pneumoniae injection into the spinal canal
• no deaths during the experimental period from meningitis induced by Streptococcus pneumoniae

muscle
N
• MCP-1 (monocyte chemoattractant protein-1) release from isolated mouse aorta smooth muscle cells (MAoSMC) by stimulation with dsRNA is normal relative to controls

homeostasis/metabolism
• recovery of post-ischemic left ventricular contractile performance is greater than controls
• reduced after both 30 and 60 minutes of reperfusion following ventricular ischemia
• reduced after 30 but not 60 minutes of reperfusion following ventricular ischemia
• relative infarction size is significantly smaller than in controls 72 hours after middle cerebral artery occlusion

liver/biliary system
• confluent foci of feathery hepatocyte degeneration due to bile acid cytotoxicity are significantly reduced compared to controls 24 hours after BDL

cardiovascular system
• recovery of post-ischemic left ventricular contractile performance is greater than controls

nervous system
• relative infarction size is significantly smaller than in controls 72 hours after middle cerebral artery occlusion

skeleton
• cultural supernatant from P gingivalis stimulated peritoneal macrophage fails to stimulate osteoclast formation

mortality/aging
• no deaths during the experimental period from meningitis induced by Streptococcus pneumoniae

cellular
• Pam3Cys-treated mice exhibit reduced Ly6Chi monocyte emigration from the bone marrow compared with similarly treated wild-type mice

hematopoietic system
• Pam3Cys-treated mice exhibit reduced Ly6Chi monocyte emigration from the bone marrow compared with similarly treated wild-type mice
• macrophages are unresponsive to macrophage activating lipopeptide 2 kD (MALP-2) and tripalitoyl cysteinyl lipopeptide (Pam3CSK4) (J:70578)
• response of macrophages to synthetic analogs of B. burgdorferi and T. pallidum lipopeptides is completely abrogated (J:70578)
• normal response of macrophages to lipopeptides of other bacterial origins (J:70578)
• activation by peptidoglycan, zymosan, and propionibacterium acnes fails (J:103464)
• reduced production of TNF alpha in response to Porphyromonas gingivalis (J:130138)
• cultural supernatant from P gingivalis stimulated peritoneal macrophage fails to stimulate osteoclast formation




Genotype
MGI:2178678
hm4
Allelic
Composition
Tlr2tm1Aki/Tlr2tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following i.p. injection with HSV-1 (KOS strain), homozygotes display delayed death and an overall reduction in mortality relative to wild-type controls: 5 of 8 homozygotes survive a challenge with 1-2 109 pfu relative to only 2 of 8 wild-type controls
• following i.p. injection of 4-day-old mice with 104 pfu of HSV-1, >60% of neonatal homozygotes survive the challenge, unlike wild-type and Tlr4tm1Aki neonates which display a >90% lethality on day 6 postinfection

immune system
N
• homozygotes display normal lymphocyte composition relative to wild-type controls
• following an i.p. injection with E. coli O55:B5-derived LPS (1.0 mg), most homozygotes succumb to LPS shock 1-5 days after challenge, with only one-fifth of mice surviving on day 6, similar to wild-type controls
• in culture, mutant B cells display a normal dose-dependent mitogenic response and normal augmentation of MHC class II expression in response to S. minnesota (Re-595) LPS relative to wild-type B cells
• lower antibody titers are seen in response to immunization with lipidated OspA (Lyme disease vaccine) alone however titers are similar to wild-type when immunized with OspA plus complete Freund's adjuvant
• mutant peritoneal macrophages show impaired TNF production in response to cell wall preparations from several Gram-positive bacteria, including S. aureus, Corynebacterium diphtheriae, and Nocardia coeliaca (J:76115)
• mutant peritoneal macrophages display a severely impaired induction of NO2- in response to S. aureus peptidoglycan plus IFN-gamma (J:76115)
• however, when cultured with 1 ng/ml of Salmonella minnesota (Re-595) LPS or synthetic E. coli-type lipid A in the presence or absence of IFN-gamma, mutant thioglycollate-elicited peritoneal macrophages exhibit normal production of IL-6 and TNF relative to wild-type controls, with no difference in the amount of NO2- produced in the presence of IFN-gamma (J:76115)
• in addition, mutant peritoneal macrophages display normal production of TNF, IL-6 and NO2- in response to purified S. aureus lipoteichoic acid (J:76115)
• Il-6 and IL-10 production after stimulation with OspA or peptoglycan are reduced compared to wild-type (J:95726)
• activation is significantly reduced after ischemia/reperfusion as measured by CD11b and GFAP induction
• unlike wild-type, mutant peritoneal macrophages fail to exhibit secretion of monocyte chemoattractant protein-1 (MCP-1) chemokine in response to HSV-1 challenge
• homozygotes produce significantly lower levels of brain MCP-1 than wild-type controls on day 1 postinfection with 109 pfu HSV-1 KOS (a dose that is 50% lethal on day 4 in wild-type but not in mutant mice)
• macrophage respond to both primary and secondary necrotic cells with reduced TNF alpha production
• mutant peritoneal macrophages fail to produce any detectable IL-6 levels in response to S. aureus peptidoglycan (J:76115)
• mutant peritoneal macrophages produce severely reduced IL-6 levels in response to challenge with herpes simplex virus 1 (HSV-1, KOS strain) (J:88174)
• mutant macrophages also fail to respond to zymosan (a TLR2 ligand), but do secrete IL-6 when challenged with LPS (a TLR4 ligand) (J:88174)
• following i.p. injection with 2 109 pfu of HSV-1 (KOS strain), homozygotes display significantly lower serum IL-6 levels than wild-type controls on day 1 postinfection (J:88174)
• in culture, mutant peritoneal macrophages fail to produce any detectable TNF levels in response to cell wall preparations from S. aureus, even at high cell wall concentrations
• mutant peritoneal macrophages show impaired TNF production in response to cell wall preparations from other Gram-positive bacteria, including Corynebacterium diphtheriae, and Nocardia coeliaca
• mutant peritoneal macrophages display a severe defect in TNF production in response to S. aureus peptidoglycan
• however, mutant peritoneal macrophages display normal production of TNF in response to purified S. aureus lipoteichoic acid
• also, mutant peritoneal macrophages show a comparable dose-dependent production of TNF in response to increasing concentrations of S.minnesota LPS, relative to wild-type macrophages
• the spirochete burden is significantly increased 2 weeks after infection with Borrelia burgdorferi, however antibody production, degree of arthritis and carditis, and time to disease resolution are the same as in wild-type mice
• following i.p. injection with herpes simplex virus 1 (HSV-1, KOS strain), only 3 of 8 homozygotes display mild symptoms excluding total paralysis or seizures, relative to 6 of 8 wild-type controls and 6 of 8 Tlr4tm1Aki homozygotes showing partial or total paralysis and/or seizures
• following i.p. injection of 4-day-old mice with 104 pfu of HSV-1, at least 50% of neonatal homozygotes remain symptom-free for the entire 2-week observation period while 12% show only mild, transient symptoms, unlike wild-type and Tlr4tm1Aki neonates which display a rapid onset of paralysis and death on day 6 postinfection
• following i.p. injection with 109 pfu HSV-1 KOS, homozygotes display lower levels of brain MCP-1 on day 1 postinfection and significantly less brain inflammatory lesions with no hemorrhage on day 4 after challenge, relative to wild-type and Tlr4tm1Aki mice
• following i.p. injection with HSV-1 (KOS strain), homozygotes display delayed death and an overall reduction in mortality relative to wild-type controls: 5 of 8 homozygotes survive a challenge with 1-2 109 pfu relative to only 2 of 8 wild-type controls
• following i.p. injection of 4-day-old mice with 104 pfu of HSV-1, >60% of neonatal homozygotes survive the challenge, unlike wild-type and Tlr4tm1Aki neonates which display a >90% lethality on day 6 postinfection

homeostasis/metabolism
• infarct size after ischemia/reperfusion is similar to controls
• left ventricular end diastole and end systole dimensions are less than for controls after ischemia/reperfusion injury
• increased fractional shortening after ischemia/reperfusion injury
• resistant to STZ induced diabetes
• unlike wild-type, mutant peritoneal macrophages fail to exhibit secretion of monocyte chemoattractant protein-1 (MCP-1) chemokine in response to HSV-1 challenge
• homozygotes produce significantly lower levels of brain MCP-1 than wild-type controls on day 1 postinfection with 109 pfu HSV-1 KOS (a dose that is 50% lethal on day 4 in wild-type but not in mutant mice)
• macrophage respond to both primary and secondary necrotic cells with reduced TNF alpha production

behavior/neurological
• after L5 spinal nerve transection, pain withdrawal threshold is reduced to 0.5 g from the normal 1g whereas control threshold drops to 0.05g measured at 7 days
• locomotor recovery impaired as measured 4-6 weeks after spinal cord injury
• after L5 spinal nerve transection, thermal threshold withdrawal latency is reduced to 3 seconds from 4.5 seconds while control latency is reduced to 2 seconds measured at 7 days

nervous system
N
• microglia induced with LPS undergo apoptosis just as do controls
• almost complete suppression of cytokine induction by supernatant from damaged sensory neurons in spinal cord glial cells
• activation is significantly reduced after ischemia/reperfusion as measured by CD11b and GFAP induction
• activation is significantly reduced after ischemia/reperfusion as measured by CD11b and GFAP induction

cardiovascular system
• lower than controls before and after myocardial infarction
• less ventricular dilation than controls after ischemia/reperfusion
• lower than controls before and after myocardial infarction
• less myocardial fibrosis in non-infarcted interstitial areas than for controls
• infarct size after ischemia/reperfusion is similar to controls
• left ventricular end diastole and end systole dimensions are less than for controls after ischemia/reperfusion injury
• increased fractional shortening after ischemia/reperfusion injury

respiratory system
• lower than controls before and after myocardial infarction

integument
• after L5 spinal nerve transection, pain withdrawal threshold is reduced to 0.5 g from the normal 1g whereas control threshold drops to 0.05g measured at 7 days
• after L5 spinal nerve transection, thermal threshold withdrawal latency is reduced to 3 seconds from 4.5 seconds while control latency is reduced to 2 seconds measured at 7 days

hematopoietic system
• lower antibody titers are seen in response to immunization with lipidated OspA (Lyme disease vaccine) alone however titers are similar to wild-type when immunized with OspA plus complete Freund's adjuvant
• mutant peritoneal macrophages show impaired TNF production in response to cell wall preparations from several Gram-positive bacteria, including S. aureus, Corynebacterium diphtheriae, and Nocardia coeliaca (J:76115)
• mutant peritoneal macrophages display a severely impaired induction of NO2- in response to S. aureus peptidoglycan plus IFN-gamma (J:76115)
• however, when cultured with 1 ng/ml of Salmonella minnesota (Re-595) LPS or synthetic E. coli-type lipid A in the presence or absence of IFN-gamma, mutant thioglycollate-elicited peritoneal macrophages exhibit normal production of IL-6 and TNF relative to wild-type controls, with no difference in the amount of NO2- produced in the presence of IFN-gamma (J:76115)
• in addition, mutant peritoneal macrophages display normal production of TNF, IL-6 and NO2- in response to purified S. aureus lipoteichoic acid (J:76115)
• Il-6 and IL-10 production after stimulation with OspA or peptoglycan are reduced compared to wild-type (J:95726)
• activation is significantly reduced after ischemia/reperfusion as measured by CD11b and GFAP induction




Genotype
MGI:4942396
hm5
Allelic
Composition
Tlr2tm1Aki/Tlr2tm1Aki
Genetic
Background
NOD.129P2-Tlr2tm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• significantly reduced susceptibility to type 1 diabetes
• 38% are diabetic at 45 weeks as compared to 74% of controls

endocrine/exocrine glands
• reduced insulitis relative to controls

immune system
• reduced insulitis relative to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
J:124334




Genotype
MGI:3625114
cx6
Allelic
Composition
Tlr2tm1Aki/Tlr2tm1Aki
Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background
B6.129P2-Tlr2tm1Aki Tlr4tm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (35 available)
Tlr4tm1Aki mutation (7 available); any Tlr4 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 5 days after lung injury, mutants show significantly increased numbers of apoptotic lung epithelial and inflammatory cells

homeostasis/metabolism
• mutant mice are more sensitive to hyperoxia; survival time of mutants after hyperoxia exposure is reduced by almost 50% compared to wild-type
• double knockout mice are more susceptible to bleomycin-induced lung injury

immune system
• hyaluronan fragment-induced expression of chemokines by peritoneal macrophages is completely abolished in double knockout mice
• 5 days after lung injury, mutant mice produce significantly lower amounts of chemotactic factor KC in the alveolar space

respiratory system
• lung tissue from mutant mice shows evidence of enhanced injury with thickened interstitium and increased inflammatory cell accumulation within the interstitium




Genotype
MGI:3707238
cx7
Allelic
Composition
Tlr2tm1Aki/Tlr2tm1Aki
Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (35 available)
Tlr4tm1Aki mutation (7 available); any Tlr4 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• significantly reduced in serum at 7 and 11 weeks of age
• in response to purified LPS, a Tlr4 agonist, or a Tlr2 agonist, macrophages do not produced TNFalpha or Il10, while production after stimulation by CpG, a Tlr9 agonist
• production of these cytokines is reduced upon stimulation with heat-killed gram negative bacteria, whereas response to gram-positive bacteria is comparable to wild-type
• TNFalpha and Il10 production is absent in response to Tlr2 or Tlr4 agonists, and is reduced in response to heat-killed gram negative bacteria

hematopoietic system
• significantly reduced in serum at 7 and 11 weeks of age
• in response to purified LPS, a Tlr4 agonist, or a Tlr2 agonist, macrophages do not produced TNFalpha or Il10, while production after stimulation by CpG, a Tlr9 agonist
• production of these cytokines is reduced upon stimulation with heat-killed gram negative bacteria, whereas response to gram-positive bacteria is comparable to wild-type




Genotype
MGI:4456174
cx8
Allelic
Composition
Tlr2tm1Aki/Tlr2tm1Aki
Tlr6tm1Aki/Tlr6tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2tm1Aki mutation (7 available); any Tlr2 mutation (35 available)
Tlr6tm1Aki mutation (1 available); any Tlr6 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• MEFs treated with diacylated (macrophage activating lipopeptide 2 kD [MALP-2]) and triacylated lipopeptides (tripalitoyl cysteinyl lipopeptide [Pam3CSK4]) fail to produce IL-6





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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory