Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm1Hma mutation
(1 available);
any
Eng mutation
(41 available)
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cardiovascular system
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• smooth muscle cell differentiation is impaired
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muscle
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• smooth muscle cell differentiation is impaired
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Allelic
Composition |
Engtm1Hma/Engtm1Hma
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm1Hma mutation
(1 available);
any
Eng mutation
(41 available)
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mortality/aging
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• embryos are present at E9.5 but die by E10.5
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embryo
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• exhibit defects in angiogenesis of the yolk sac, with fewer and less well-developed vascular channels and reduced numbers of red blood cells in many embryos
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• exhibit developmental delay of about 0.5 day, as indicated by a delay in fusion of the dorsal aorta
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• exhibit defects in hematopoiesis of the yolk sac, with reduced numbers of blood cells in the yolk sac
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cardiovascular system
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• occasional embryos have a reduced cephalic capillary bed, however the appearance of the vasculature in the embryo (except for in the yolk sac) for the most part is normal
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• exhibit defects in angiogenesis of the yolk sac, with fewer and less well-developed vascular channels and reduced numbers of red blood cells in many embryos
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• almost all embryos have dilated outflow tracts
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• the endothelial surface of the truncal cushions fails to organize in about half of homozygous embryos
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• many embryos have abnormal cardiac looping
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• almost all embryos have enlarged ventricles
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growth/size/body
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• exhibit developmental delay of about 0.5 day, as indicated by a delay in fusion of the dorsal aorta
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hematopoietic system
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• exhibit defects in hematopoiesis of the yolk sac, with reduced numbers of blood cells in the yolk sac
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homeostasis/metabolism
muscle
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm1Hma mutation
(1 available);
any
Eng mutation
(41 available)
|
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cardiovascular system
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• occasional mice exhibit extensive dilated and weak-walled vessels
• elastin support fibers surrounding fragile vessels are disorganized and sparsely distributed
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• smooth muscle cells surrounding the fragile vessels are disorganized and sparsely distributed
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muscle
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• smooth muscle cells surrounding the fragile vessels are disorganized and sparsely distributed
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Analysis Tools