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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-cre)93Kln
transgene insertion 93, Rudiger Klein
MGI:2176754
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Mecp2tm1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J MGI:3624685
cn2
Bdnftm3Jae/Bdnftm3Jae
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J MGI:5306255
cn3
Bdnftm3Jae/Bdnf+
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J MGI:5306256
cn4
Col1a1tm8(CAG-BDNF)Jae/Col1a1+
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J MGI:5306257
cn5
Bdnftm3Jae/Bdnftm3Jae
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * CBA/J MGI:2176756
cn6
Gt(ROSA)26Sortm2(RNAi:Braf)Rkuhn/Gt(ROSA)26Sor+
Tg(Camk2a-cre)93Kln/?
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3785791


Genotype
MGI:3624685
cn1
Allelic
Composition
Mecp2tm1Jae/Y
Tg(Camk2a-cre)93Kln/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (25 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants appear healthy for up to 3 months when they begin to exhibit an ataxic gait
• mutants appear healthy for up to 3 months when they begin to show reduced nocturnal activity

growth/size/body
• 7 of 11 become overweight and obese at 10 weeks of age or older
• mutants appear healthy for up to 3 months when they begin to gain weight

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 7.5 months of age
• exhibit smaller neuronal bodies in the cortex and hippocampus but not in the cerebellum

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:67909




Genotype
MGI:5306255
cn2
Allelic
Composition
Bdnftm3Jae/Bdnftm3Jae
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation (1 available); any Bdnf mutation (16 available)
Mecp2tm1.1Jae mutation (2 available); any Mecp2 mutation (25 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• life span is shorter than in Mecp2 single homozygous mice

behavior/neurological
• dramatic reduction in wheel running activity at 4 weeks of age

nervous system
• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:106973




Genotype
MGI:5306256
cn3
Allelic
Composition
Bdnftm3Jae/Bdnf+
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation (1 available); any Bdnf mutation (16 available)
Mecp2tm1.1Jae mutation (2 available); any Mecp2 mutation (25 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• life span is shorter than in Mecp2 single hemizygous mice but longer than in mutant mice homozygous for the Bdnf allele




Genotype
MGI:5306257
cn4
Allelic
Composition
Col1a1tm8(CAG-BDNF)Jae/Col1a1+
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm8(CAG-BDNF)Jae mutation (0 available); any Col1a1 mutation (88 available)
Mecp2tm1.1Jae mutation (2 available); any Mecp2 mutation (25 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• life span is significantly longer than in Mecp2 single hemizygous mice

behavior/neurological
N
• overexpression of BDNF improves locomotor function compared to Mecp2 single hemizygous mice at 6 weeks of age

nervous system
• decreased compared to wild-type littermates but modestly increased compared to Mecp2 single hemizygous mice
• firing rate is increased compared to Mecp2 single hemizygous mice




Genotype
MGI:2176756
cn5
Allelic
Composition
Bdnftm3Jae/Bdnftm3Jae
Tg(Camk2a-cre)93Kln/0
Genetic
Background
involves: 129S4/SvJae * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation (1 available); any Bdnf mutation (16 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• food intake is 74% higher than in controls
• display increased inter-male aggression
• mutants by 4 weeks of age become agitated and active and appear stressed when handled
• mutants continue to appear agitated after the habituation period in a novel cage, with a 40% reduction in activity after an hour of habituation compared to 72% reduction in controls
• in a light/dark exploration test, mutants take 3.6 times longer to make the first transition from the dark to the light compartment, they spend half as much time in the light zone compared with controls and only make 35% the number of dark-to-light zone transitions compared to controls
• hindlimb clasping
• hyperactive when stressed

growth/size/body
• increased body weight is seen at 8 weeks of age and by 30 weeks, males and females are 80 and 150% heavier than controls, respectively
• 10% increase in naso-anal length compared with controls

homeostasis/metabolism
• abnormal starvation response in mutants as indicated by continued elevation of leptin, increased reduction in glucose levels, and attenuated NPY levels compared to controls after 48 hours of fasting
• glucose levels are 70% higher than in controls
• serum insulin levels are elevated 6-fold in obese mutants but normal in younger lean mutants
• serum leptin levels are elevated 15-fold in obese mutants but normal in younger lean mutants
• cholesterol levels are increased by 54% compared to controls

reproductive system
• sterility in obese females but not younger lean females, indicating that sterility is secondary to the effect of obesity

nervous system
• decreased size of CA2 neurons
• decreased size of the olfactory glomeruli




Genotype
MGI:3785791
cn6
Allelic
Composition
Gt(ROSA)26Sortm2(RNAi:Braf)Rkuhn/Gt(ROSA)26Sor+
Tg(Camk2a-cre)93Kln/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(RNAi:Braf)Rkuhn mutation (0 available); any Gt(ROSA)26Sor mutation (313 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory