Analysis Tools
reproductive system
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• impaired double strand break processing and loss of preleptotene pairing
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Allele Symbol Allele Name Allele ID |
Dmc1tm1Jcs targeted mutation 1, John C Schimenti MGI:2176331 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired double strand break processing and loss of preleptotene pairing
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• approximately one-third the weight of those of controls
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• approximately one-third the weight of those of controls
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(J:47308)
(J:183982)
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• defects during prophase of meiosis I beginning at, or prior to, the pachytene stage
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• arrest during prophase of meiosis I at a zygotene-like stage in which chromosomal synapsis was not initiated
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• approximately one-third the weight of those of controls
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• approximately one-third the weight of those of controls
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(J:47308)
(J:183982)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Ovary histopathology of the Dmc1Mei11/Dmc+ and Dmc1Mei11/Dmc1tm1Jcs mice
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• 60% of females exhibit a relatively normal ovarian morphology with developing and antral-stage follicles, although with fewer follicles than in wild-type
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• 40% of females exhibit residual ovaries devoid of follicles
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• spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes
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• 60% of females exhibit a relatively normal ovarian morphology with developing and antral-stage follicles, although with fewer follicles than in wild-type
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• 40% of females exhibit residual ovaries devoid of follicles
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• testes undergo complete prophase I meiotic arrest, without signs of postmeiotic differentiation as is seen in heterozygous Dmc1Mei11 males
• defective chromosome synapsis and double strand break repair in spermatocytes; spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes
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• spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• both male and female mice are fully fertile without any detectable defects in gametogenesis; females exhibit normal primordial follicle numbers, while males display normal testis weights, sperm counts and testis histology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells
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• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells
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• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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