Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tektm1Dmt mutation
(1 available);
any
Tek mutation
(92 available)
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embryo
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N |
• allantois explants form normal vascular networks
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Allelic
Composition |
Tektm1Dmt/Tektm1Dmt
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * CD-1 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tektm1Dmt mutation
(1 available);
any
Tek mutation
(92 available)
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mortality/aging
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• homozygous embryos are present at E9.5 but absent at E10.5
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cardiovascular system
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• gaps are seen in the blood vessel walls in the head and electron microscopy revealed gaps in the vascular endothelial cells of the perinuclear plexus in the head
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• no pericytes are found around the vascular endothelial cells
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• vascular branching and sprouting are impaired and the complexity of the vascular network is decreased
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• absent myocardial trabeculations at E9.5
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• at E9.5 the endothelium lining the myocardium is less intricately folded and the endocardial lining appears collapsed and retracted from the myocardial wall
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• most homozygous embryos have hemorrhages in the head
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embryo
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• at E9.5 the vitteline vasculature fails to reorganize into a mature branched network; however, the immature plexus forms normally
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hematopoietic system
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• multilineage hematopoietic stem cell clusters in the omphalomesenteric and vitelline arteries are absent and the number of hematopoietic cells produced in vitro is severely reduced
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nervous system
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• most homozygous embryos have hemorrhages in the head
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muscle
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• absent myocardial trabeculations at E9.5
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Allelic
Composition |
Rasa1tm1Paw/Rasa1tm1Paw
Tektm1Dmt/Tektm1Dmt
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Genetic
Background |
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa1tm1Paw mutation
(0 available);
any
Rasa1 mutation
(34 available)
Tektm1Dmt mutation
(1 available);
any
Tek mutation
(92 available)
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cardiovascular system
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• at 16 somite stage, thinning of the dorsal aorta and aberrant ventral arteries seen
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• heart is surrounded by a distended pericardium by E9.5
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• by E9.5, local ruptures in the vasculature and leakage of blood into the body cavity occurred
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embryo
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• endothelial cells failed to reorganize into a vascular network
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mortality/aging
cardiovascular system
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• blood vessels in the dorsal, posterior portion of the mouse are enlarged and highly distorted compared to in wild-type mice
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• blood vessel development fails to proceed to the dorsal portion of the body unlike in wild-type mice
• vessel integrity is compromised compared to in wild-type mice
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• mice exhibit poor branching structures of the blood vessels in the head unlike wild-type mice
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• blood vessels fail to organize into large and small vessels unlike in wild-type mice
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• yolk sac vasculature is underdeveloped and lacks major blood vessels unlike in wild-type mice
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• myocardial trabeculation in the ventricle is absent
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• at E9.5, heart development is poor
• mice exhibit reduced endocardial tissue in the common atrial and ventricular chambers compared to in wild-type mice
• mice exhibit thin myocardial layer, poor maintenance of endocardial contact, and absence of trabeculations unlike in wild-type mice
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embryo
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• yolk sac vasculature is underdeveloped and lacks major blood vessels unlike in wild-type mice
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• at E9.5, necrotic tissue is occasionally observed
• at E10.5, necrosis is widespread
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• somites are disorganized and necrotic unlike in wild-type mice
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• remodeling of primary yolk sac capillary plexus fails
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homeostasis/metabolism
growth/size/body
muscle
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• myocardial trabeculation in the ventricle is absent
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nervous system
cellular
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• at E9.5, necrotic tissue is occasionally observed
• at E10.5, necrosis is widespread
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mortality/aging
cardiovascular system
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• maintenance of blood vessels in the head and extremities is poor
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• atrial and ventricular endocardium is poorly maintained
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homeostasis/metabolism
Analysis Tools