About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Chrdtm1Emdr
targeted mutation 1, EM De Robertis
MGI:2157350
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Chrdtm1Emdr/Chrdtm1Emdr 129S6.129-Chrdtm1Emdr MGI:3841293
hm2
Chrdtm1Emdr/Chrdtm1Emdr either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J) MGI:2676545
hm3
Chrdtm1Emdr/Chrdtm1Emdr involves: 129S1/Sv * 129X1/SvJ MGI:3819787
hm4
Chrdtm1Emdr/Chrdtm1Emdr involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:3691482
hm5
Chrdtm1Emdr/Chrdtm1Emdr involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3818961
cx6
Chrdtm1Emdr/Chrdtm1Emdr
Tbx1m1Jlk/Tbx1m1Jlk
129/Sv-Tbx1m1Jlk Chrdtm1Emdr MGI:3841289
cx7
Bmpertm1Emdr/Bmpertm1Emdr
Chrdtm1Emdr/Chrdtm1Emdr
involves: 129 * C57BL/6 * SJL MGI:3818262
cx8
Chrdtm1Emdr/Chrdtm1Emdr
Nogtm1Amc/Nogtm1Amc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:2662585
cx9
Chrdtm1Emdr/Chrdtm1Emdr
Nogtm1Amc/Nogtm1Amc
involves: 129S1/Sv * 129X1/SvJ * ICR MGI:2173453
cx10
Chrdtm1Emdr/Chrdtm1Emdr
Nodaltm1Rob/Nodal+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:4819097
cx11
Chrdtm1Emdr/Chrdtm1Emdr
Smad3tm1Xfw/Smad3+
involves: 129/Sv * 129S1/Sv * 129X1/SvJ MGI:4819103
cx12
Chrdtm1Emdr/Chrdtm1Emdr
Smad3tm1Xfw/Smad3tm1Xfw
involves: 129/Sv * 129S1/Sv * 129X1/SvJ MGI:4819104
cx13
Chrdtm1Emdr/Chrdtm1Emdr
Twsg1tm1.1Mboc/Twsg1tm1.1Mboc
involves: 129/Sv * C57BL/6 * FVB/N MGI:3830685


Genotype
MGI:3841293
hm1
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Genetic
Background
129S6.129-Chrdtm1Emdr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cleft palate and ear and cardiovascular abnormalities in Chrdtm1Emdr/Chrdtm1Emdr mice

craniofacial
• sometimes
• mandibular truncation with a penetrance of about 20%
• ears are abnormally located at E15.5

skeleton
• sometimes
• mandibular truncation with a penetrance of about 20%

cardiovascular system

digestive/alimentary system

embryo

hearing/vestibular/ear
• ears are abnormally located at E15.5
• ears fail to form auricle structure

hematopoietic system

immune system

endocrine/exocrine glands

growth/size/body
• ears are abnormally located at E15.5




Genotype
MGI:2676545
hm2
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Genetic
Background
either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 86% of homozygotes are still alive at E14.5; however, a sharp increase in lethality is noted after E14.5
• only 49% (95 out of 194) of homozygotes are recovered at birth
• a few attempt, unsuccessfully, to inflate their lungs
• most are still born due to cardio-respiratory failure
• 12% of homozygous mutant embryos are resorbed at E8.5 (50 out of 57 expected)
• no homozygotes with an abnormal allantois survive past E8.5

embryo
• at E10.5, homozygotes show absence of neural crest cell migration through the peripharyngeal region into the proximity of the heart, resulting in lack of outflow tract septation
• at E8.5, 4 of 50 homozygotes show early ventralization of the mesoderm, with increased extraembryonic mesodermal cells noted in the allantois
• at E8.5, 4 of 50 homozygotes display a reduced body size
• at E8.5, 4 of 50 homozygotes display a reduced embryonic region, while the remaining 46 appear morphologically normal
• at E9.0, the second (hyoid) pharyngeal arch is absent
• in addition, pharyngeal arches three to six fail to form
• at E8.5, 4 of 50 homozygotes display absence of trunk mesoderm
• at E8.5, 4 of 50 homozygotes exhibit a significantly hypoplastic and poorly differentiated neural plate
• at E8.5, 4 of 50 homozygotes display absence of a notochord
• homozygotes that die perinatally show absence of an anterior notochord at E14.5
• at E9.5, the pharyngeal pouches are reduced to a single swelling in the anterior-most region
• at E8.5, 4 of 50 homozygotes display absence of somites
• at E8.5, 4 of 50 homozygotes display an enlarged allantois with an abundance of extraembryonic mesodermal cells

craniofacial
• newborn homozygotes display fused basioccipital and basisphenoid bones while the alisphenoid appears normal
• at E14.5, the basioccipital and basisphenoid cartilages are fused; the ossification centre of the basioccipital is narrower and extends into the basisphenoid
• newborn homozygotes display a hypoplastic presphenoid bone
• newborn homozygotes lack the squama temporalis
• newborn homozygotes a smaller temporal bone
• newborn homozygotes display a shorter zygomatic arch
• newborn homozygotes exhibit hyoid bone hypoplasia
• newborn homozygotes lack the coronoid, condylar and angular processes
• newborn homozygotes lack the angular process
• newborn homozygotes lack the condylar process
• newborn homozygotes lack the coronoid process
• newborn homozygotes display an abnormally small jaw
• newborn homozygotes lack a secondary palate
• at E9.0, the second (hyoid) pharyngeal arch is absent
• in addition, pharyngeal arches three to six fail to form
• the palatal shelves fail to extend medially to form the secondary palate
• newborn homozygotes have external ears that are set abnormally close to the eyes
• newborn homozygotes exhibit small external ears

cardiovascular system
• at E14.5, homozygotes exhibit an enlarged anterior spinal artery
• in newborns, the pulmonary arteries originate directly from the proximal truncus arteriosus, resulting in the absence of a common pulmonary trunk
• at birth, part of the aortic arch is absent
• depending of the laterality of the descending aorta, the right or left subclavian arteries adopt an abnormal retrooesophageal position
• 40% of newborn homozygotes display an abnormal right-turning aortic arch; the descending aorta is placed on the right side of the esophagus and the left subclavian runs posterior to it
• absence of the brachiocephalic artery
• in newborns, the common carotid arteries directly join the truncus arteriosus, resulting in the absence of the brachiocephalic artery and part of the aortic arch
• at E14.5, homozygotes exhibit persistent truncus arteriosus
• at E14.5, homozygotes exhibit severe hemorrhage

skeleton
• newborn homozygotes display fused basioccipital and basisphenoid bones while the alisphenoid appears normal
• at E14.5, the basioccipital and basisphenoid cartilages are fused; the ossification centre of the basioccipital is narrower and extends into the basisphenoid
• newborn homozygotes display a hypoplastic presphenoid bone
• newborn homozygotes lack the squama temporalis
• newborn homozygotes a smaller temporal bone
• newborn homozygotes display a shorter zygomatic arch
• newborn homozygotes exhibit hyoid bone hypoplasia
• newborn homozygotes lack the coronoid, condylar and angular processes
• newborn homozygotes lack the angular process
• newborn homozygotes lack the condylar process
• newborn homozygotes lack the coronoid process
• newborn homozygotes display an abnormally small jaw
• newborn homozygotes display reduced laryngeal cartilages
• newborn homozygotes exhibit cricoid cartilage hypoplasia
• newborn homozygotes exhibit thyroid cartilage hypoplasia
• newborn homozygotes lack the anterior arch of the atlas
• at E14.5, homozygotes display underdeveloped vertebral neural arches
• newborn homozygotes exhibit reduced vertebral bodies, with delayed ossification and occasional loss of other elements of the vertebrae e.g. spinous processes, neural arches and the anterior arch of the atlas

hearing/vestibular/ear
• newborn homozygotes have external ears that are set abnormally close to the eyes
• newborn homozygotes exhibit small external ears
• at E9.0, otic vesicles are reduced to half their normal diameter
• a conspicuous indentation is noted in the neck region
• newborn homozygotes display a malformed and reduced otic capsule
• newborn homozygotes exhibit hypoplasia/absence of the inner ear
• at E14.5, homozygotes exhibit absence of the Eustachian tube
• newborn homozygotes display a malformed tympanic ring
• newborn homozygotes display a reduced tympanic ring

endocrine/exocrine glands
• newborn homozygotes lack parathyroid glands (derivatives of pharyngeal pouches 3 and 4)
• newborn homozygotes lack a thymus (a derivative of the third pharyngeal pouch)
• newborn homozygotes exhibit a thyroid gland of irregular shape
• newborn homozygotes display thyroid hypoplasia

nervous system
• at E8.5, 4 of 50 homozygotes exhibit a significantly hypoplastic and poorly differentiated neural plate
• at E9.5, homozygotes display severe cranial sensory ganglia abnormalities, including loss of epibranchial placode-derived ganglia
• at E9.5, the vestibulocochlear ganglia are deformed and displaced
• at E9.5, the geniculate ganglion is either extremely reduced or entirely absent
• at E9.5, the petrosal ganglion is either extremely reduced or entirely absent
• at E9.5, the petrosal ganglion is either extremely reduced or entirely absent
• at E9.5, the trigeminal ganglia are deformed and displaced
• at E9.5, the nodose ganglion is either extremely reduced or entirely absent
• at E9.5, the nodose ganglion is either extremely reduced or entirely absent

respiratory system
• newborn homozygotes display reduced laryngeal cartilages
• newborn homozygotes exhibit cricoid cartilage hypoplasia
• newborn homozygotes exhibit thyroid cartilage hypoplasia
• newborn homozygotes exhibit malformations in the oropharynx region
• at E14.5, homozygotes exhibit a significantly reduced pharynx
• at E9.5, homozygotes display a reduction of pharyngeal endoderm
• newborn homozygotes display a reduced tracheal size

hematopoietic system
• newborn homozygotes lack a thymus (a derivative of the third pharyngeal pouch)

homeostasis/metabolism
• newborn homozygotes appear cyanotic
• at E14.5, homozygotes exhibit severe edema

digestive/alimentary system
• newborn homozygotes lack a secondary palate
• the palatal shelves fail to extend medially to form the secondary palate
• newborn homozygotes lack an esophagus

growth/size/body
• newborn homozygotes lack a secondary palate
• the palatal shelves fail to extend medially to form the secondary palate
• newborn homozygotes have external ears that are set abnormally close to the eyes
• newborn homozygotes exhibit small external ears
• at E8.5, 4 of 50 homozygotes display a reduced body size
• newborn homozygotes display microcephaly
• newborn homozygotes are slightly smaller than wild-type littermates

immune system
• newborn homozygotes lack a thymus (a derivative of the third pharyngeal pouch)

muscle

cellular
• at E10.5, homozygotes show absence of neural crest cell migration through the peripharyngeal region into the proximity of the heart, resulting in lack of outflow tract septation




Genotype
MGI:3819787
hm3
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 50% of animals die perinatally

nervous system
N
• at 2-3 months of age brains show normal gross hippocampal morphology as well as normal dendritic structure
• axon terminals at hippocampal synapses have more docked vesicles per active zone length than wild-type synapses
• LTP induction is enhanced with high frequency stimulation of afferent fibers compared to wild-type controls
• frequency of mEPSCs in hippocampal slices is significantly increased compared to controls while amplitudes are similar
• in mutant CA1 region hippocampal slices significantly enhanced paired-pulse facilitation (PPF) is observed compared to wild-type slices at interpulse intervals <100 ms

behavior/neurological
• in Y-maze test mice enter formerly closed (novel) arm of maze less frequently than wild-type controls during recall trial (3 hours after acquisition phase)
• in Morris water maze mice display improved ability to find hidden platform using spatial cues and require less time to escape from water on second day of experiment; after 10 days of training wild-type and mutants show similar performance
• mice display lower sniffing behavior to a novel object placed inside their box during a 15 minute test
• in center of open field mice exhibit hyperactivity and run faster than wild-type controls




Genotype
MGI:3691482
hm4
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are stillborn with normal early development and neural induction

embryo
• homozygotes display defects in pharyngeal organization

craniofacial
• homozygotes display defects in pharyngeal organization

cardiovascular system
• homozygotes display defects in cardiovascular organization

hearing/vestibular/ear
• at E12.5, homozygotes exhibit abnormal inner and outer ear development




Genotype
MGI:3818961
hm5
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• Background Sensitivity: mice are viable on this genetic background without the phenotypic abnormalities previously reported for Chrdtm1Emdr homozygotes

renal/urinary system
N
• bladder neck-urethra angle is same as in wild-type embryos

reproductive system
N
• budding pattern of developing prostate is identical to wild-type embryos several days after initiation of prostatic budding




Genotype
MGI:3841289
cx6
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Tbx1m1Jlk/Tbx1m1Jlk
Genetic
Background
129/Sv-Tbx1m1Jlk Chrdtm1Emdr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
Tbx1m1Jlk mutation (0 available); any Tbx1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• mandibular truncation with a penetrance of about 20%
• 100% penetrance
• malformed
• 100% penetrance

hematopoietic system
• 100% penetrance

cardiovascular system
• 100% penetrance

skeleton
• mandibular truncation with a penetrance of about 20%

digestive/alimentary system
• 100% penetrance

hearing/vestibular/ear
• malformed
• 100% penetrance

immune system
• 100% penetrance

endocrine/exocrine glands
• 100% penetrance

growth/size/body
• 100% penetrance
• malformed
• 100% penetrance




Genotype
MGI:3818262
cx7
Allelic
Composition
Bmpertm1Emdr/Bmpertm1Emdr
Chrdtm1Emdr/Chrdtm1Emdr
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpertm1Emdr mutation (1 available); any Bmper mutation (30 available)
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• mice exhibit the abnormalities observed in both Bmpertm1Emdr and Chrdtm1Emdr single homozygotes
• the thirteenth thoracic vertebrae displays a posterior homeotic transformation with loss of the thirteenth rib
• the thirteenth thoracic vertebrae displays a posterior homeotic transformation with loss of the thirteenth rib
• some mice exhibit a weak recovery of neural arches in the lumbar region compared to in Bmpertm1Emdr homozygotes




Genotype
MGI:2662585
cx8
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Nogtm1Amc/Nogtm1Amc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
Nogtm1Amc mutation (3 available); any Nog mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no double homozygotes are recovered among neonates
• only 2 (out of 20 expected) double homozygotes are recovered close to term, both undergoing resorption
• only 3 (out of 10 expected) double homozygotes are recovered at E12.5
• only 14 (out of 18 expected) double homozygotes are recovered at E8.5

nervous system
• double homozygotes recovered at E12.5 lack extensive areas of the forebrain, anterior to the hindbrain
• at E12.5, telencephalon and diencephalon are reduced to a single thin neural vesicle
• anterior defects are noted at the start of neurulation (E7.5); however, the AVE is initially formed
• in contrast, formation of the midbrain and more posterior brain structures remains unaffected
• double homozygotes recovered close to term exhibit holoprosencephaly
• double homozygotes recovered at E12.5 display a more severe phenotype resembling aprosencephaly
• at E8.5, double homozygotes show significant loss of forebrain tissue
• at E12.5, telencephalon and diencephalon are reduced to a single thin neural vesicle
• at E12.5, telencephalon and diencephalon are reduced to a single thin neural vesicle

craniofacial
• holoprosencephalic double homozygotes recovered close to term exhibit agnathia
• double homozygotes recovered at E12.5 lack nasal (olfactory) placodes
• double homozygotes recovered at E12.5 lack extensive facial structures
• holoprosencephalic double homozygotes recovered close to term exhibit a single nasal pit (proboscis)

skeleton
• holoprosencephalic double homozygotes recovered close to term exhibit agnathia
• at E12.5, double homozygotes show absence of sclerotome in cervical regions

vision/eye
• holoprosencephalic double homozygotes recovered close to term exhibit cyclopia
• double homozygotes recovered at E12.5 lack eyes

taste/olfaction
• double homozygotes recovered at E12.5 lack nasal (olfactory) placodes

respiratory system
• double homozygotes recovered at E12.5 lack nasal (olfactory) placodes
• at E8.5, the trachea fails to form, and a common tracheo-esophageal duct connects the pharynx to the lungs and stomach
• at E8.5, the anterior pharynx is reduced

cardiovascular system
• at early somites stages, double homozygotes exhibit inverted cardiac looping, with the prospective heart ventricle looping to the left

embryo
• double homozygotes show defects in dorsal mesendoderm development (notochord, sclerotome, foregut)
• at E8.5, 4 of 7 double homozygotes display heart inversions, indicating randomization of the heart situs
• at early somites stages, double homozygotes display a reduction in anterior neural folds
• at E12.5, double homozygotes show absence of a notochord in cervical regions

digestive/alimentary system
• at E8.5, the trachea fails to form, and a common tracheo-esophageal duct connects the pharynx to the lungs and stomach

growth/size/body
• double homozygotes recovered at E12.5 lack extensive facial structures
• holoprosencephalic double homozygotes recovered close to term exhibit a single nasal pit (proboscis)




Genotype
MGI:2173453
cx9
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Nogtm1Amc/Nogtm1Amc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
Nogtm1Amc mutation (3 available); any Nog mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E9.0 mutants show no directional looping of the heart; cardiac looping is abnormal or reversed in >90% of embryos




Genotype
MGI:4819097
cx10
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Nodaltm1Rob/Nodal+
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
Nodaltm1Rob mutation (1 available); any Nodal mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in 14 of 19 mice with defects in anterior midline tissues

embryo
• expression analysis indicates defects in patterning and function in the anterior most axial mesendoderm
• 23% (19 of 83) show defects in anterior midline tissues
• 14 of these 19 show holoprosencephaly in association with anterior body truncation and fused first pharyngeal arches
• fused in 14 of 19 mice with defects in anterior midline tissues
• expression analysis indicates impairment in ADE specification
• expression analysis indicates defects in patterning and function

cardiovascular system
• cardiac laterality defects are seen in 5 mice

craniofacial
• fused in 14 of 19 mice with defects in anterior midline tissues

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
holoprosencephaly DOID:4621 OMIM:PS236100
J:161524




Genotype
MGI:4819103
cx11
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Smad3tm1Xfw/Smad3+
Genetic
Background
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
Smad3tm1Xfw mutation (0 available); any Smad3 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• no defects are detected in anterior midline tissues




Genotype
MGI:4819104
cx12
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Smad3tm1Xfw/Smad3tm1Xfw
Genetic
Background
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
Smad3tm1Xfw mutation (0 available); any Smad3 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• no defects are detected in anterior midline tissues




Genotype
MGI:3830685
cx13
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Twsg1tm1.1Mboc/Twsg1tm1.1Mboc
Genetic
Background
involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (31 available)
Twsg1tm1.1Mboc mutation (0 available); any Twsg1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

craniofacial

skeleton

nervous system
N
• no alobar holoprosencephaly at E15.5-E17.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory