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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1.1Brn
targeted mutation 1.1, Anton Berns
MGI:2156651
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1.1Brn/Trp53tm1.1Brn involves: 129P2/OlaHsd * BALB/cJ * FVB/N MGI:3831429
cn2
 		Trp53tm1Brn/Trp53tm1.1Brn involves: 129P2/OlaHsd MGI:4437464
cn3
 		Trp53tm1.1Brn/Trp53tm3Tyj
Tg(KRT14-cre)8Brn/? 		involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N * SKH1 MGI:3716946
cn4
 		Trp53tm1.1Brn/Trp53+
Tg(KRT14-cre)8Brn/? 		involves: 129P2/OlaHsd * FVB/N * SKH1 MGI:3716948
cn5
 		Trp53tm1.1Brn/Trp53tm1.1Brn
Tg(KRT14-cre)8Brn/? 		involves: 129P2/OlaHsd * FVB/N * SKH1 MGI:3716947
cx6
 		Atmintm1.1Jhh/Atmintm1.1Jhh
Trp53tm1.1Brn/Trp53tm1.1Brn 		involves: 129P2/OlaHsd * C57BL/6 MGI:4881343


Genotype
MGI:3831429
hm1
Allelic
Composition		 Trp53tm1.1Brn/Trp53tm1.1Brn
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Brn mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:73028 )
• mice exhibit a similar increase in tumor incidence with the same spectrum as in other Trp53 null mice
decreased tumor latency ( J:73028 )
• median tumor-free survival is 116 days compared to 515 in heterozygotes




Genotype
MGI:4437464
cn2
Allelic
Composition		 Trp53tm1Brn/Trp53tm1.1Brn
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Brn mutation (0 available); any Trp53 mutation (232 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenocarcinoma incidence ( J:86077 , J:157319 )
• in all mice treated with a cre-expressing adenovirus (J:86077)
• in 6 of 7 mice following treatment with cre-expressing adenovirus (J:157319)

respiratory system
increased lung adenocarcinoma incidence ( J:86077 , J:157319 )
• in all mice treated with a cre-expressing adenovirus (J:86077)
• in 6 of 7 mice following treatment with cre-expressing adenovirus (J:157319)




Genotype
MGI:3716946
cn3
Allelic
Composition		 Trp53tm1.1Brn/Trp53tm3Tyj
Tg(KRT14-cre)8Brn/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N * SKH1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1.1Brn mutation (0 available); any Trp53 mutation (232 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:121734 )
• skin tumors develop between 200 and 300 days
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma
increased lymphoma incidence ( J:121734 )
• developed in one mouse

cellular
decreased cellular sensitivity to ultraviolet irradiation ( J:121734 )
• fewer CASP3+ cells area found following UVB treatment when compared to wild-type mice
• the reduction in apoptotic cells is slightly greater in homozygotes than in heterozygotes

integument
increased skin tumor incidence ( J:121734 )
• skin tumors develop between 200 and 300 days
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma




Genotype
MGI:3716948
cn4
Allelic
Composition		 Trp53tm1.1Brn/Trp53+
Tg(KRT14-cre)8Brn/?
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N * SKH1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1.1Brn mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:121734 )
• skin tumors develop between 500 and 600 days
• UVB exposure results in 2.4+/-0.6 tumors at day 100 compared to 6.5+/-1.4 in Trp53tm3Tyj Tg(KRT14-cre)8Brn heterozygotes and 0.6+/-0.2 in wild-type mice
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma

cellular
decreased cellular sensitivity to ultraviolet irradiation ( J:121734 )
• fewer CASP3+ cells area found following UVB treatment when compared to wild-type mice
• the reduction in apoptotic cells is slightly greater in homozygotes than in heterozygotes

integument
increased skin tumor incidence ( J:121734 )
• skin tumors develop between 500 and 600 days
• UVB exposure results in 2.4+/-0.6 tumors at day 100 compared to 6.5+/-1.4 in Trp53tm3Tyj Tg(KRT14-cre)8Brn heterozygotes and 0.6+/-0.2 in wild-type mice
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma




Genotype
MGI:3716947
cn5
Allelic
Composition		 Trp53tm1.1Brn/Trp53tm1.1Brn
Tg(KRT14-cre)8Brn/?
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N * SKH1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1.1Brn mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:121734 )
• skin tumors develop between 200 and 300 days
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma

cellular
decreased cellular sensitivity to ultraviolet irradiation ( J:121734 )
• fewer CASP3+ cells area found following UVB treatment when compared to wild-type mice
• the reduction in apoptotic cells is slightly greater in homozygotes than in heterozygotes

integument
increased skin tumor incidence ( J:121734 )
• skin tumors develop between 200 and 300 days
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma




Genotype
MGI:4881343
cx6
Allelic
Composition		 Atmintm1.1Jhh/Atmintm1.1Jhh
Trp53tm1.1Brn/Trp53tm1.1Brn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.1Jhh mutation (2 available); any Atmin mutation (38 available)
Trp53tm1.1Brn mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:167544 )
• no mice are present at weaning




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory