Analysis Tools
mortality/aging
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• about 50% die by P14 compared to about 96% on a congenic C57BL/6J background
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Allele Symbol Allele Name Allele ID |
Abl1tm1Mlg targeted mutation 1, Richard C Mulligan MGI:2153718 |
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| Summary |
11 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 50% die by P14 compared to about 96% on a congenic C57BL/6J background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E18.5 the heart weight to body weight ratio is increased
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• at E18.5 and P0
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• Background Sensitivity: about 90% die between P0 an P1 compared to about 10% perinatal lethality on a mixed 129 and C57BL/6J background
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• Background Sensitivity: only 4% survive to P14 compared to about 50% survival on coisogenic 129 or mixed 129 and C57BL/6J backgrounds
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• Background Sensitivity: defects in heart morphology develop after E14.5 and peak around birth, in contrast mice on a mixed 129 and C57BL/6J background have grossly normal heart morphology
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• nuclei shapes are highly irregular at E18.5 and P0
• at E18.5 mitochondria are randomly distributed and large hollow mitochondria characterized by loss of vesicles and cristae are present
• at E18.5 some sarcomeres are fragmented and disorganized with abnormal Z-discs
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• at E18.5 and P0
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• orientation of the fibers is highly irregular at E18.5 and P0
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• the ventricular compact layer is expanded at P0
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• at E18.5
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• at E18.5 the heart weight to body weight ratio is increased
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• at E18.5 and P0
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• almost complete disappearance of the ventricle lumens at P0
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• the trabecular layer is expanded at P0
• interstitial space between cardiomyocytes is increased
• no signs of fibrosis are detected
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• thicker at P0
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• at E18.5
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• at E18.5 the numbers of mitotic cells are modestly increased in the ventricles and interventricular septum and the increase in mitosis is primarily confined to cardiomyocytes
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• nuclei shapes are highly irregular at E18.5 and P0
• at E18.5 mitochondria are randomly distributed and large hollow mitochondria characterized by loss of vesicles and cristae are present
• at E18.5 some sarcomeres are fragmented and disorganized with abnormal Z-discs
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• at E18.5 and P0
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• orientation of the fibers is highly irregular at E18.5 and P0
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• the trabecular layer is expanded at P0
• interstitial space between cardiomyocytes is increased
• no signs of fibrosis are detected
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• the ventricular compact layer is expanded at P0
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• at E18.5 the numbers of mitotic cells are modestly increased in the ventricles and interventricular septum and the increase in mitosis is primarily confined to cardiomyocytes
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• at E18.5 the numbers of mitotic cells are modestly increased in the ventricles and interventricular septum and the increase in mitosis is primarily confined to cardiomyocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 65% of mutants die 1-2 weeks after birth
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• about 10% are dead at birth compared to about 90% neonatal lethality on a congenic C57BL/6J background
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• 65% of mutants die 1-2 weeks after birth
(J:72875)
• about 50% die by P14 compared to about 96% on a congenic C57BL/6J background
(J:156743)
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• the few mutants that survive to 3-4 months of age develop megaesophagus
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• seen in many mutants
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• 85% of mutants develop T and B cell lymphopenia
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• thymus is severely deficient in thymocytes, with predominantly thymic stroma remaining; the few remaining thymocytes are single positives
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• seen in many mutants
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• the few mutants that survive to 3-4 months of age develop aspiration pneumonia secondary to the megaesophagus
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• the few mutants that survive to 3-4 months of age develop megaesophagus
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• the few mutants that survive to 3-4 months of age develop anal prolapse
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• hepatocytes of runted pups contain fatty vacuoles and are degenerating
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| N |
• Background Sensitivity: unlike mice on a C57BL/6J congenic background, heart morphology, even in mice that die perinatally, is grossly normal
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• seen in many mutants
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• 85% of mutants develop T and B cell lymphopenia
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• thymus is severely deficient in thymocytes, with predominantly thymic stroma remaining; the few remaining thymocytes are single positives
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• seen in many mutants
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• the few mutants that survive to 3-4 months of age develop aspiration pneumonia secondary to the megaesophagus
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• seen in many mutants
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• thymus is severely deficient in thymocytes, with predominantly thymic stroma remaining; the few remaining thymocytes are single positives
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• very low numbers reach weaning age; mortality among survivors continues after weaning
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• between 0 and <5% of homozygotes are detected at weaning, with significant post natal mortality being observed
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• observed in survivors
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• foreshortened crania are observed with high prevalence in survivors
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• prolapsed recta are observed frequently in survivors
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• variable decreases of B lymphocyte progenitors are observed
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• abnormal shape is observed with high prevalence in survivors
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• abnormal shape is observed with high prevalence in survivors
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• observed in survivors
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• foreshortened crania are observed with high prevalence in survivors
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• observed in survivors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants die between E15.5 and E16
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• seen in most mutants
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• the pericardial sac of many mutants is enlarged and edematous
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• seen in most mutants
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• the peritoneum of many mutants is enlarged and edematous
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• seen in most mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 60% of the expected numbers of mutants are recovered postnatally
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• survivors are runted at birth, however they survive well into adulthood
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die before E11
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• mutants exhibit delayed appearance of Map2-positive early neurons in the neuroepithelium
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• neuroepithelial cells show alterations in actin cytoskeleton
• the neuroepithelium collapses into the lumen of the neural tube at E10.25
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• delay of neural tube closure is seen at E9.5, with the neural tube of most embryos closed by E10.25, although in some embryos, gaps remain at one or more fusion points in the head region
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• neuroepithelial cells show alterations in actin cytoskeleton
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• embryos from E10.5-E11 have massive numbers of apoptotic cells in all tissues of the body
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• mutants exhibit delayed appearance of Map2-positive early neurons in the neuroepithelium
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• embryos from E10.5-E11 have massive numbers of apoptotic cells in all tissues of the body
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• neuroepithelial cells show alterations in actin cytoskeleton
• the neuroepithelium collapses into the lumen of the neural tube at E10.25
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• delay of neural tube closure is seen at E9.5, with the neural tube of most embryos closed by E10.25, although in some embryos, gaps remain at one or more fusion points in the head region
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• very low numbers reach weaning age; mortality among survivors continues after weaning with all (6/6) survivors dying within 3-6 months
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• low numbers of homozygotes are detected at weaning
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• animals exhibit bloated gastrointestinal tracts at time of death
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• abnormal shape is observed with high prevalence in survivors
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• abnormal shape is observed with high prevalence in survivors
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• survivors often succumb to infections
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• animals show long-term survival rates comparable to controls
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• variable decreases of B lymphocyte progenitors are observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• animals show long-term survival rates comparable to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• animals show long-term survival rates comparable to controls
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• variable decreases of B lymphocyte progenitors are observed
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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