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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxb3tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2151773
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxb3tm1Mrc/Hoxb3tm1Mrc involves: 129S4/SvJae * C57BL/6 MGI:2675269
cx2
 		Hoxa3tm3Mrc/Hoxa3tm3Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc 		involves: 129S4/SvJae MGI:3836912
cx3
 		Hoxa3tm1Mrc/Hoxa3tm1Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J MGI:3038610
cx4
 		Hoxa3tm1Mrc/Hoxa3+
Hoxb3tm1Mrc/Hoxb3tm1Mrc 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J MGI:3611934
cx5
 		Hoxb3tm1Mrc/Hoxb3tm1Mrc
Hoxd3tm1Mrc/Hoxd3tm1Mrc 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J MGI:3611935


Genotype
MGI:2675269
hm1
Allelic
Composition		 Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:45337 )
• a small number of newborns are found dead soon after birth, consistent with the low frequency of the IXth cranial nerve defects

skeleton
fusion of atlas and odontoid process ( J:45337 )
• the anterior arch of the atlas is joined by an ossified bridge to the dens of the axis, low penetrance

nervous system
fusion of glossopharyngeal and vagus nerve ( J:45337 )
• partial deletion of cranial nerve IX or fusion to cranial nerve X at relatively low penetrance




Genotype
MGI:3836912
cx2
Allelic
Composition		 Hoxa3tm3Mrc/Hoxa3tm3Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm3Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal somatic motor system morphology ( J:86041 )
• incomplete loss of somatic motor neurons restricted to r5
• possibly involving a "change of fate" to V2 interneurons




Genotype
MGI:3038610
cx3
Allelic
Composition		 Hoxa3tm1Mrc/Hoxa3tm1Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm1Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:45337 )
• died within hours of birth

skeleton
abnormal supraoccipital bone morphology ( J:45337 )
• defective formation, 100% penetrance
abnormal hyoid bone greater horn morphology ( J:45337 )
• the greater horn is almost entirely missing
abnormal hyoid bone lesser horn morphology ( J:45337 )
• progressive loss of lesser horn
abnormal cricoid cartilage morphology ( J:45337 )
• small and sometimes fused to thyroid cartilage
thyroid cartilage hypoplasia ( J:45337 )
• poorly formed
abnormal cervical atlas morphology ( J:45337 )
• reduced neural arch
fusion of atlas and occipital bones ( J:45337 )
• anterior arch of atlas fused to basioccipital bone
abnormal cervical axis morphology ( J:45337 )
• reduced neural arch

endocrine/exocrine glands
abnormal ultimobranchial body morphology ( J:46523 )
• variable development of ultimobranchial bodies, sometimes absent, sometimes persistent in adults
absent ultimobranchial body ( J:46523 )
• sometimes absent
persistent ultimobranchial bodies ( J:46523 )
• sometimes persistent in adults
abnormal thyroid gland isthmus morphology ( J:46523 )
• absent or defective thyroid isthmus

respiratory system
abnormal cricoid cartilage morphology ( J:45337 )
• small and sometimes fused to thyroid cartilage
thyroid cartilage hypoplasia ( J:45337 )
• poorly formed

nervous system
decreased sensory neuron number ( J:88581 )
• absence of noradrenergic visceral sensory interneurons and associated expansion of the somatic sensory interneuron domain in rhombomere 5

craniofacial
abnormal supraoccipital bone morphology ( J:45337 )
• defective formation, 100% penetrance
fusion of atlas and occipital bones ( J:45337 )
• anterior arch of atlas fused to basioccipital bone
abnormal hyoid bone greater horn morphology ( J:45337 )
• the greater horn is almost entirely missing
abnormal hyoid bone lesser horn morphology ( J:45337 )
• progressive loss of lesser horn

embryo
abnormal ultimobranchial body morphology ( J:46523 )
• variable development of ultimobranchial bodies, sometimes absent, sometimes persistent in adults
absent ultimobranchial body ( J:46523 )
• sometimes absent
persistent ultimobranchial bodies ( J:46523 )
• sometimes persistent in adults




Genotype
MGI:3611934
cx4
Allelic
Composition		 Hoxa3tm1Mrc/Hoxa3+
Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm1Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
ectopic thymus ( J:46523 )
• lobes of thymus displaced anteriorly

endocrine/exocrine glands
ectopic parathyroid gland ( J:46523 )
• ectopic parathyroids near the anterior ends of the thymus
ectopic thymus ( J:46523 )
• lobes of thymus displaced anteriorly

hematopoietic system
ectopic thymus ( J:46523 )
• lobes of thymus displaced anteriorly




Genotype
MGI:3611935
cx5
Allelic
Composition		 Hoxb3tm1Mrc/Hoxb3tm1Mrc
Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
Hoxd3tm1Mrc mutation (0 available); any Hoxd3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:45337 )
• about 50% die at birth
postnatal lethality, complete penetrance ( J:45337 )
• all homozygotes dead by the end of the first week after birth

skeleton
abnormal hyoid bone morphology ( J:45337 )
• greater horn sometimes fused to thyroid cartilage
hyoid bone hypoplasia ( J:19447 )
• reduced in size
abnormal thyroid cartilage morphology ( J:19447 )
• dorsally associated cartilage of thyroid cartilage is missing
abnormal cervical atlas morphology ( J:19447 )
• neural arch resembles more posterior cervical vertebrae (C3-C5)
absent cervical atlas ( J:19447 )
• atlas missing, with small cartilage remnants

nervous system
fusion of glossopharyngeal and vagus nerve ( J:45337 )
• partial deletion of cranial nerve IX or fusion to cranial nerve X, increased penetrance

endocrine/exocrine glands
abnormal ultimobranchial body morphology ( J:46523 )
• low penetrance of partially fused ultimobranchial bodies

respiratory system
abnormal thyroid cartilage morphology ( J:19447 )
• dorsally associated cartilage of thyroid cartilage is missing

craniofacial
abnormal hyoid bone morphology ( J:45337 )
• greater horn sometimes fused to thyroid cartilage
hyoid bone hypoplasia ( J:19447 )
• reduced in size

embryo
abnormal ultimobranchial body morphology ( J:46523 )
• low penetrance of partially fused ultimobranchial bodies




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory