Hoxd3^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxd3^tm1Mrc
• Name: homeobox D3; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:1857959
• Synonyms: Hoxd3-
• Gene: Hoxd3 Location: Chr2:74542337-74578615 bp, + strand Genetic Position: Chr2, 44.13 cM, cytoband C2
• Alliance: Hoxd3^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15678
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into sequences encoding the second helix of the homeobox domain. (J:15678)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd3 Mutation: 13 strains or lines available

Notes

Homozygous mutant mice have anterior homeotic transformations of cervical vertebrae I and II, the atlas and axis vertebrae. The atlas is fused with the skull, while the axis is altered to an "atlas-like" conformation (J:15678). Although null mutations of Hoxd3 and its paralog, Hoxa3, cause no defects in common, they interact in double mutant mice, the atlas being completely deleted (J:19447).

References

• Original: J:15678 Condie BG, et al., Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development. 1993 Nov;119(3):579-95
• All: 7 reference(s)