All Phenotypes Fcer2a<tm1Max> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fcer2a^tm1Max/Fcer2a^tm1Max	involves: C57BL/6	MGI:3851191
hm2	Fcer2a^tm1Max/Fcer2a^tm1Max	involves: C57BL/6J	MGI:5502735
cx3	Fcer1a^tm1Knt/Fcer1a^tm1Knt Fcer2a^tm1Max/Fcer2a^tm1Max	B6.Cg-Fcer1a^tm1Knt Fcer2a^tm1Max	MGI:3851202
cx4	Fcer1a^tm1Knt/Fcer1a^tm1Knt Fcer2a^tm1Max/Fcer2a^tm1Max Fcgr1^tm1Jsv/Fcgr1^tm1Jsv Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Fcgr3^tm1Jsv/Fcgr3^tm1Jsv	B6.Cg-Fcgr2b^tm1Ttk Fcgr3^tm1Jsv Fcer1a^tm1Knt Fcgr1^tm1Jsv Fcer2a^tm1Max	MGI:3851204
cx5	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J	MGI:5502734
cx6	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1⁺	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J	MGI:5502736

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage chemotaxis ( J:57738 )

• in an airway hyperresponsiveness model, about 4-fold more macrophages are found in the lungs compared to controls

impaired eosinophil recruitment ( J:57738 )

• in an airway hyperresponsiveness model, eosinophils numbers found in the airways are 18-fold less than those found in controls

increased IgE level ( J:18952 , J:57738 , J:107857 )

• IgE levels are 6-12 fold higher than controls after immunization with a T cell-dependent antigen (J:18952)

• IgE levels are two-fold higher than controls (J:18952)

• serum levels of total IgE are higher than controls (1241 mean ng/ml versus 748 mean ng/ml) (J:57738)

• antigen specific IgE levels are similar to wild-type after airway challenge with OVA (J:57738)

• antigen-specific IgE levels after immunization are twice that of immunized controls (J:107857)

decreased IgG1 level ( J:18952 )

• IgG1 levels are decreased about two-fold

• antigen-specific IgG1 levels will increase more than controls upon immunization with a T cell-dependent antigen

decreased IgG2b level ( J:18952 )

• IgG2b levels are decreased about two-fold

increased IgM level ( J:18952 )

• IgM levels are increased about two-fold higher than controls upon immunization with a T cell-indpendent antigen

increased susceptibility to type I hypersensitivity reaction ( J:57738 )

• the airway responsiveness of OVA-treated CD23-deficient mice to OVA challenge is two-fold higher than in the controls

• the inflammatory cells recruited by airway challenge differ from controls with 5-fold less cells than controls

• the predominant cell type in the inflammatory infiltrate is macrophages compared to eosinophils in controls

digestive/alimentary system

abnormal intestinal absorption ( J:107857 )

• rapid transcytosis of antigen across enterocytes is not evident in sensitized mutant mice as occurs in sensitized mutant mice

cellular

abnormal macrophage chemotaxis ( J:57738 )

• in an airway hyperresponsiveness model, about 4-fold more macrophages are found in the lungs compared to controls

hematopoietic system

abnormal macrophage chemotaxis ( J:57738 )

• in an airway hyperresponsiveness model, about 4-fold more macrophages are found in the lungs compared to controls

impaired eosinophil recruitment ( J:57738 )

• in an airway hyperresponsiveness model, eosinophils numbers found in the airways are 18-fold less than those found in controls

increased IgE level ( J:18952 , J:57738 , J:107857 )

• IgE levels are two-fold higher than controls (J:18952)

• IgE levels are 6-12 fold higher than controls after immunization with a T cell-dependent antigen (J:18952)

• serum levels of total IgE are higher than controls (1241 mean ng/ml versus 748 mean ng/ml) (J:57738)

• antigen specific IgE levels are similar to wild-type after airway challenge with OVA (J:57738)

• antigen-specific IgE levels after immunization are twice that of immunized controls (J:107857)

decreased IgG1 level ( J:18952 )

• IgG1 levels are decreased about two-fold

• antigen-specific IgG1 levels will increase more than controls upon immunization with a T cell-dependent antigen

decreased IgG2b level ( J:18952 )

• IgG2b levels are decreased about two-fold

increased IgM level ( J:18952 )

• IgM levels are increased about two-fold higher than controls upon immunization with a T cell-indpendent antigen

Allelic Composition	Fcer2a^tm1Max/Fcer2a^tm1Max
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer2a^tm1Max mutation (0 available); any Fcer2a mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

Allelic Composition	Fcer1a^tm1Knt/Fcer1a^tm1Knt Fcer2a^tm1Max/Fcer2a^tm1Max
Genetic Background	B6.Cg-Fcer1a^tm1Knt Fcer2a^tm1Max

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mast cell physiology ( J:144620 )

• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally

• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells

hematopoietic system

abnormal mast cell physiology ( J:144620 )

• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally

• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells

Allelic Composition	Fcer1a^tm1Knt/Fcer1a^tm1Knt Fcer2a^tm1Max/Fcer2a^tm1Max Fcgr1^tm1Jsv/Fcgr1^tm1Jsv Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Fcgr3^tm1Jsv/Fcgr3^tm1Jsv
Genetic Background	B6.Cg-Fcgr2b^tm1Ttk Fcgr3^tm1Jsv Fcer1a^tm1Knt Fcgr1^tm1Jsv Fcer2a^tm1Max

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1a^tm1Knt mutation (3 available); any Fcer1a mutation (21 available)
Fcer2a^tm1Max mutation (0 available); any Fcer2a mutation (24 available)
Fcgr1^tm1Jsv mutation (4 available); any Fcgr1 mutation (34 available)
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Fcgr3^tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mast cell physiology ( J:144620 )

• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally

• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells

abnormal macrophage physiology ( J:144620 )

• macrophages fail to react to IgE complexes

increased susceptibility to type I hypersensitivity reaction ( J:144620 )

• mice fail to initiate an airway inflammatory response when IgE immune complexes are administered intranasally

hematopoietic system

abnormal mast cell physiology ( J:144620 )

• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally

• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells

abnormal macrophage physiology ( J:144620 )

• macrophages fail to react to IgE complexes

Allelic Composition	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer2a^tm1Max mutation (0 available); any Fcer2a mutation (24 available)
Ighg1^tm1.1Pyu mutation (0 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

immune system

abnormal immunoglobulin level ( J:198154 )

• mice exhibit expression of membrane IgE in vitro but not in vivo

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

hematopoietic system

abnormal immunoglobulin level ( J:198154 )

• mice exhibit expression of membrane IgE in vitro but not in vivo

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Allelic Composition	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1⁺
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

immune system

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG1 level ( J:198154 )

• absent in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

hematopoietic system

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG1 level ( J:198154 )

• absent in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

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