All Phenotypes Rxra<tm1Ipc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rxra^tm1Ipc
targeted mutation 1, Pierre Chambon
MGI:1857511

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rxra^tm1Ipc/Rxra^tm1Ipc	involves: 129S2/SvPas	MGI:3629417
ht2	Rxra^tm1Ipc/Rxra^tm2Ipc	involves: 129S2/SvPas * C57BL/6	MGI:3839232
cn3	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0	involves: 129S2/SvPas	MGI:3622670
cn4	Rxra^tm1Ipc/Rxra^tm1Ipc Tg(Myh6-Rxra)41Pcn/0	involves: 129S2/SvPas	MGI:5906923
cn5	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3629408
cx6	Rxra^tm1Ipc/Rxra^tm1Ipc Rxrb^tm1Mma/Rxrb^tm1Mma	involves: 129S2/SvPas * C57BL/6	MGI:3839233

Allelic Composition	Rxra^tm1Ipc/Rxra^tm1Ipc
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Ipc mutation (0 available); any Rxra mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:60351 )

• no fetuses are recovered after E16.5

cardiovascular system

ventricular hypoplasia ( J:60351 )

• ventricular myocardial hypoplasia at E14.5

integument

abnormal skin morphology ( J:109090 )

• phenotype of newborn mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

abnormal skin condition ( J:109090 )

• skin of newborns appears dull

Allelic Composition	Rxra^tm1Ipc/Rxra^tm2Ipc
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Ipc mutation (0 available); any Rxra mutation (30 available)
Rxra^tm2Ipc mutation (0 available); any Rxra mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye development ( J:146761 )

• 1of 4 mice displayed a characteristic Rxra null phenotype

• 3 of 4 mice displayed a bilateral persistent and hyperplasic primary vitreous body

Allelic Composition	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Ipc mutation (0 available); any Rxra mutation (30 available)
Rxra^tm4Ipc mutation (0 available); any Rxra mutation (30 available)
Rxrb^tm1Mma mutation (0 available); any Rxrb mutation (26 available)
Rxrb^tm1Pcn mutation (0 available); any Rxrb mutation (26 available)
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation

immune system

increased immunoglobulin level ( J:102470 )

• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type

integument

alopecia ( J:102470 )

• mice develop early hair loss observed around the eyes and the dorsal skin at weeks 3 to 5

hair follicle degeneration ( J:102470 )

abnormal skin morphology ( J:109090 )

• phenotype of adult mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

dermal hyperplasia ( J:102470 )

• at week 5, mice show a dense dermal hyperplasia

mixed cellular infiltration to dermis ( J:102470 )

• mutants show a weaker infiltration of the dermis

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

• with treatment with the Ppard agonist L165041, epidermis of adult mice is similar to control mice with lipids forming a continuous ribbon on top of the cornified layer

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

epidermal hyperplasia ( J:102470 )

• at week 5, mice show a dense dermal hyperplasia and hyperplasic epidermis

hematopoietic system

increased immunoglobulin level ( J:102470 )

• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type

Allelic Composition	Rxra^tm1Ipc/Rxra^tm1Ipc Tg(Myh6-Rxra)41Pcn/0
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Ipc mutation (0 available); any Rxra mutation (30 available)
Tg(Myh6-Rxra)41Pcn mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:60351 )

• no fetuses are recovered after E16.5

cardiovascular system

ventricular hypoplasia ( J:60351 )

• ventricular myocardial hypoplasia at E14.5

Allelic Composition	Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre)1Ipc/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:109090 )

• phenotype of newborn mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

abnormal skin condition ( J:109090 )

• skin of newborns appears dull

Allelic Composition	Rxra^tm1Ipc/Rxra^tm1Ipc Rxrb^tm1Mma/Rxrb^tm1Mma
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Ipc mutation (0 available); any Rxra mutation (30 available)
Rxrb^tm1Mma mutation (0 available); any Rxrb mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal corneal stroma morphology ( J:146761 )

• the ventral portion is thickened at E14.5

ventral rotation of lens ( J:146761 )

• ventral rotation is seen at E14.5

abnormal eye development ( J:146761 )

• at E14.5 all mice have a persistent and hyperplasic primary vitreous body

abnormal eyelid morphology ( J:146761 )

• closer eyelid folds in mice at E14.5

abnormal ocular fundus morphology ( J:146761 )

optic disk coloboma ( J:146761 )

• small optic disc coloboma is seen in most mice at E14.5

abnormal retina morphology ( J:146761 )

• shortened ventral retina at E14.5

cardiovascular system

ventricular myocardium compact layer hypoplasia ( J:146761 )

• hypoplasia of the compact layer of the ventricular myocardium is seen in about 50% of mice

abnormal conotruncus septation ( J:146761 )

• agenesis of the conotruncal septum is occasionally seen at E14.5

nervous system

optic disk coloboma ( J:146761 )

• small optic disc coloboma is seen in most mice at E14.5

muscle

ventricular myocardium compact layer hypoplasia ( J:146761 )

• hypoplasia of the compact layer of the ventricular myocardium is seen in about 50% of mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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