About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4tm2Nnt
targeted mutation 2, Nancy Noben-Trauth
MGI:1857195
Summary 3 genotypes


Genotype
MGI:5432612
hm1
Allelic
Composition		 Il4tm2Nnt/Il4tm2Nnt
Genetic
Background		 BALB/c-Il4tm2Nnt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm2Nnt mutation (3 available); any Il4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )
• increased mortality following acute infection with Schistosoma mansoni compared to wild-type mice

immune system
ileum inflammation ( J:60609 )
• marked distension and inflammation of the ileum in S. mansoni infected mice
• circulating levels of LPS in S. mansoni infected mice are elevated indicating impaired integrity of the gut
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice
abnormal splenocyte physiology ( J:60609 )
• display a diminished type 2 cytokine response in response to soluble schistosome egg antigens compared to wild-type cells
abnormal susceptibility to infection ( J:60609 )
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice
increased susceptibility to parasitic infection ( J:60609 )
• increase in S. mansoni infection induced liver damage measured by plasma aspartate aminotransferase levels compared to wild-type mice
• marked distension and inflammation of the ileum in S. mansoni infected mice and impaired parasite egg excretion compared to wild-type mice
increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )
• increased mortality following acute infection with Schistosoma mansoni compared to wild-type mice

hematopoietic system
abnormal splenocyte physiology ( J:60609 )
• display a diminished type 2 cytokine response in response to soluble schistosome egg antigens compared to wild-type cells

digestive/alimentary system
ileum inflammation ( J:60609 )
• marked distension and inflammation of the ileum in S. mansoni infected mice
• circulating levels of LPS in S. mansoni infected mice are elevated indicating impaired integrity of the gut
• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice




Genotype
MGI:2179958
hm2
Allelic
Composition		 Il4tm2Nnt/Il4tm2Nnt
Genetic
Background		 BALB/c-Il4tm2Nnt/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm2Nnt mutation (3 available); any Il4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
alveolar process atrophy ( J:147935 )
• increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

immune system
abnormal dendritic cell differentiation ( J:141937 )
• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds
decreased IgE level ( J:31486 )
• reduced serum concentrations of IgE, however lymphocyte composition and function comparable to wild-type controls
decreased IgG1 level ( J:31486 )
• reduced serum concentrations of IgG1, however lymphocyte composition and function comparable to wild-type controls
abnormal dendritic cell antigen presentation ( J:141937 )
• memory CD4 T cells activated by mutant DCs from inflamed lungs secrete low levels of Th2 cytokines
increased interferon-gamma secretion ( J:141937 )
• T cells from mice sensitized and challenged with OVA produce more IFN-gamma than controls
decreased interleukin-13 secretion ( J:141937 )
• lymphocytes from mice sensitized and challenged with OVA produce less IL-13 than controls
decreased interleukin-5 secretion ( J:141937 )
• lymphocytes from mice sensitized and challenged with OVA produce less IL-5 than controls
decreased susceptibility to autoimmune disorder ( J:141937 )
• mice fail to develop blood eosinophilia after being sensitized and challenged with OVA peptide
• airway hyperresponsiveness still occurs in these mice though less mucosal cells are found in the inflamed airway

hematopoietic system
abnormal dendritic cell differentiation ( J:141937 )
• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds
decreased IgE level ( J:31486 )
• reduced serum concentrations of IgE, however lymphocyte composition and function comparable to wild-type controls
decreased IgG1 level ( J:31486 )
• reduced serum concentrations of IgG1, however lymphocyte composition and function comparable to wild-type controls

craniofacial
alveolar process atrophy ( J:147935 )
• increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

skeleton
alveolar process atrophy ( J:147935 )
• increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks

cellular
abnormal dendritic cell differentiation ( J:141937 )
• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced by two-thirds

renal/urinary system
abnormal kidney physiology ( J:84825 )
• functional and histological markers for damage after ischemia are elevated




Genotype
MGI:3721951
cx3
Allelic
Composition		 Il4tm2Nnt/Il4tm2Nnt
Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic
Background		 C.Cg-Tgfb1tm1Doe Il4tm2Nnt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm2Nnt mutation (3 available); any Il4 mutation (42 available)
Tgfb1tm1Doe mutation (4 available); any Tgfb1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:69346 )
• average survival is 13.6 days (range 10-19.5 days)

homeostasis/metabolism
increased circulating alanine transaminase level ( J:69346 )
• extensive inflammation is observed

immune system

liver/biliary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory