Phenotypes associated with this allele

• Allele Symbol: Kit^W-sh
• Allele Name: sash
• Allele ID: MGI:1856265
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^W-sh/Kit^W-sh	B6.Cg-Kit^W-sh/HNihrJaeBsmGlliJ	MGI:7469798
hm2	Kit^W-sh/Kit^W-sh	involves: 101/H * C3H/HeH	MGI:3029930
hm3	Kit^W-sh/Kit^W-sh	involves: 101/H * C3H/HeH * CBA	MGI:5461040
hm4	Kit^W-sh/Kit^W-sh	involves: C57BL/6J	MGI:5517571
ht5	Kit^W-sh/Kit^+	involves: 101/H * C3H/HeH * CBA	MGI:3029932
ht6	Kit^W-sh/Kit^W-v	involves: 101/H * C3H/HeH	MGI:3711169
cx7	Kit^W-sh/Kit^W-sh Lyn^tm1Ard/Lyn^tm1Ard	involves: 101 * 129P2/OlaHsd * C3H/HeH	MGI:4462257

Genotype
MGI:7469798

hm1

• Allelic Composition: Kit^W-sh/Kit^W-sh
• Genetic Background: B6.Cg-Kit^W-sh/HNihrJaeBsmGlliJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:275367 )

• in a model of passive systemic anaphylaxis, mice sensitized i.p. with anti-DNP IgE and challenged with DNP-HAS fail to exhibit induction of hypothermia at 50 min after antigen challenge

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:275367 )

• when sensitized i.p. with anti-DNP IgE and challenged i.p. with DNP-HAS, mice exhibit lack of a mast cell-dependent anaphylactic response with no significant drop in body core temperature noted at 50 min post-challenge

Genotype
MGI:3029930

hm2

• Allelic Composition: Kit^W-sh/Kit^W-sh
• Genetic Background: involves: 101/H * C3H/HeH

immune system

decreased mast cell degranulation ( J:157470 )

• following chloroquine treatment

decreased mast cell number ( J:145444 )

• mice are described as being mast cell deficient

increased susceptibility to parasitic infection ( J:163761 )

• after second infestation to ticks, mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice

• however, transfer of wild-type bone marrow restores repletion

pigmentation

abnormal coat/hair pigmentation ( J:6857 )

• the coat is white except for small patches on or near the ears and, infrequently, at the base of the tail

behavior/neurological

impaired behavioral response to xenobiotic ( J:157470 )

• mice exhibit reduced chloroquine-induced scratching compared with similarly treated wild-type mice

hematopoietic system

decreased mast cell degranulation ( J:157470 )

• following chloroquine treatment

abnormal definitive hematopoiesis ( J:6857 )

abnormal erythrocyte cell number ( J:6857 )

decreased erythrocyte cell number ( J:6857 )

• on this background,lower than normal mean hematocrit values were found but did not manifest as an anemia

decreased mast cell number ( J:145444 )

• mice are described as being mast cell deficient

integument

abnormal coat/hair pigmentation ( J:6857 )

• the coat is white except for small patches on or near the ears and, infrequently, at the base of the tail

cellular

decreased mast cell degranulation ( J:157470 )

• following chloroquine treatment

Genotype
MGI:5461040

hm3

• Allelic Composition: Kit^W-sh/Kit^W-sh
• Genetic Background: involves: 101/H * C3H/HeH * CBA

integument

absent coat pigmentation ( J:24351 )

• classic black eyes and white coat

pigmentation

absent coat pigmentation ( J:24351 )

• classic black eyes and white coat

Genotype
MGI:5517571

hm4

• Allelic Composition: Kit^W-sh/Kit^W-sh
• Genetic Background: involves: C57BL/6J

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:197334 )

• following intradermally injection of BV-PLA2 or PLA2G3 into the mouse ear, mice fail to exhibit IgE and antigen induced dose-dependent vascular leakage or augmented passive cutaneous anaphylaxis unlike wild-type mice

cardiovascular system

abnormal vascular permeability ( J:197334 )

• following intradermally injection of BV-PLA2 or PLA2G3 into the mouse ear, mice fail to exhibit IgE and antigen induced dose-dependent vascular leakage or augmented passive cutaneous anaphylaxis unlike wild-type mice

Genotype
MGI:3029932

ht5

• Allelic Composition: Kit^W-sh/Kit⁺
• Genetic Background: involves: 101/H * C3H/HeH * CBA

pigmentation

variable body spotting ( J:24351 )

• appears as a distinctive broad white sash

integument

variable body spotting ( J:24351 )

• appears as a distinctive broad white sash

Genotype
MGI:3711169

ht6

• Allelic Composition: Kit^W-sh/Kit^W-v
• Genetic Background: involves: 101/H * C3H/HeH

hematopoietic system

abnormal definitive hematopoiesis ( J:6857 )

macrocytic anemia ( J:6857 )

• anemia is mild

abnormal erythrocyte cell number ( J:6857 )

decreased erythrocyte cell number ( J:6857 )

pigmentation

abnormal coat/hair pigmentation ( J:6857 )

• most mice had classic white coat and black eyes

• some had small patches of pigmented hair on the ears

absent coat pigmentation ( J:6857 )

integument

abnormal coat/hair pigmentation ( J:6857 )

• most mice had classic white coat and black eyes

• some had small patches of pigmented hair on the ears

absent coat pigmentation ( J:6857 )

Genotype
MGI:4462257

cx7

• Allelic Composition: Kit^W-sh/Kit^W-sh; Lyn^tm1Ard/Lyn^tm1Ard
• Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

hematopoietic system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• of IgE isotype

increased anti-double stranded DNA antibody level ( J:161523 )

• of IgE isotype

glomerulonephritis ( J:161523 )

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

renal/urinary system

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

glomerulonephritis ( J:161523 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:161523