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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
MitfMi-wh
white
MGI:1856088
Summary 20 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
MitfMi-wh/MitfMi-wh B6.Cg-MitfMi-wh MGI:3762342
hm2
MitfMi-wh/MitfMi-wh involves: C57BL * C57BL/6J * DBA MGI:4455019
hm3
MitfMi-wh/MitfMi-wh involves: C57BL * DBA MGI:3044413
ht4
MitfMi-wh/Mitf+ involves: C57BL * DBA MGI:3044414
ht5
MitfMi-wh/Mitfmi-sp B6.Cg-MitfMi-wh/Mitfmi-sp/J MGI:3821718
ht6
MitfMi-b/MitfMi-wh involves: 101/Rl * C3H/Rl MGI:4410316
ht7
Mitftm5.1Arnh/MitfMi-wh involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316609
ht8
Mitftm6.1Arnh/MitfMi-wh involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316621
ht9
Mitftm4.1Arnh/MitfMi-wh involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316634
ht10
Mitftm4Arnh/MitfMi-wh involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316596
ht11
Mitftm5Arnh/MitfMi-wh involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316597
ht12
Mitftm6Arnh/MitfMi-wh involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316599
ht13
Mitftm7Arnh/MitfMi-wh involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316601
ht14
Mitftm7.1Arnh/MitfMi-wh involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316616
ht15
MitfMi-wh/Mitfmi-x NZB/Mac MGI:2663064
cx16
MitfMi-wh/MitfMi-wh
Tfe3tm1Est/Tfe3tm1Est
either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA) MGI:3044424
cx17
MitfMi-wh/MitfMi-wh
Tfectm1Est/Tfectm1Est
either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA) MGI:3044429
cx18
MitfMi-wh/MitfMi-wh
Tfe3tm1Est/Tfe3tm1Est
Tfectm1Est/Tfectm1Est
either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA) MGI:4455023
cx19
MitfMi-wh/MitfMi-wh
Tfebtm1Est/Tfeb+
involves: 129S1/Sv * C57BL * C57BL/6J * DBA MGI:4455024
cx20
MitfMi-wh/Mitf+
Myo5ad/Myo5ad
involves: C57BL * DBA MGI:3762341


Genotype
MGI:3762342
hm1
Allelic
Composition
MitfMi-wh/MitfMi-wh
Genetic
Background
B6.Cg-MitfMi-wh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• pigment granules are absent at E11
• at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
• after E12 in some area the cells are columnar rather than cuboidal
• at all stages the number of mitoses is increased compared to control pigment layers
• pigment granules are absent from the pigment layer at E11
• after E12, a few pigment granules may be found in the front edge of the pigment layer
• at birth a few pigment granules are present near the iris

vision/eye
• slightly reduced in size from E13 onwards
• irregularly formed surrounding less than half of the spherical lens
• at E12 the choroid fissure is mostly closed but the joining of the retinal nervous layer is not smooth and a large retinal eversion is present at the rear of the optic cup where the fissure fails to close
• in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
• slight increase in diameter at E11
• shorter and somewhat greater in diameter at E11.5 and E12
• slightly smaller at birth
• the lens fills the space normally occupied by the vitreous body
• pigment granules are absent at E11
• at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
• after E12 in some area the cells are columnar rather than cuboidal
• at all stages the number of mitoses is increased compared to control pigment layers
• pigment granules are absent from the pigment layer at E11
• after E12, a few pigment granules may be found in the front edge of the pigment layer
• at birth a few pigment granules are present near the iris
• at birth, the layers are less clearly defined
• at birth the choroid fissure is irregularly closed in the anterior eye and open from the posterior part of the lens to the rear of the optic cup
• in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure

skeleton
N
• unlike MitfMi homozygotes no skeletal abnormalities are seen

homeostasis/metabolism
• bleed time of only 1 minute after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls




Genotype
MGI:4455019
hm2
Allelic
Composition
MitfMi-wh/MitfMi-wh
Genetic
Background
involves: C57BL * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• eyes are slightly pigmented

skeleton
N
• normal bone development and mice do not develop osteopetrosis

vision/eye
• eyes are slightly pigmented

integument




Genotype
MGI:3044413
hm3
Allelic
Composition
MitfMi-wh/MitfMi-wh
Genetic
Background
involves: C57BL * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

MitfMi-wh/+ and MitfMi-wh/MitfMi-wh and control

pigmentation
• coat color is indistinguishable from that of Tyrc homozygotes (J:13058)
• the coat is entirely lacking pigment (J:125080)
• eyes are pink and pigmentless
• little or no pigment in the iris

vision/eye
• eyes are pink and pigmentless
• little or no pigment in the iris
• eye size appears reduced compared to f Tyrc homozygotes (J:13058)
• the eyes are only mildly reduced in size (J:125080)

growth/size/body
• reduced body size compared to f Tyrc homozygotes

reproductive system
• litter size is reduced in homozygous female to homozygous male crosses

hearing/vestibular/ear
• no section of the cochlear duct was ever found to be normal
• abnormal in its entirety
• the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

nervous system

integument
• coat color is indistinguishable from that of Tyrc homozygotes (J:13058)
• the coat is entirely lacking pigment (J:125080)




Genotype
MGI:3044414
ht4
Allelic
Composition
MitfMi-wh/Mitf+
Genetic
Background
involves: C57BL * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

MitfMi-wh/+

pigmentation
• coat color is gray and somewhat lighter than that of Myo5ad homozygotes (J:13058)
• coat color darkens slightly with age (J:13058)
• small spots may occur on the back, but spotting is not found on the head
• reduced foot pigmentation
• reduced tail pigmentation
• moderate dilution of the iris pigmentation
• eyes are a very dark ruby color

limbs/digits/tail
• reduced tail pigmentation

vision/eye
• moderate dilution of the iris pigmentation
• eyes are a very dark ruby color

integument
• coat color is gray and somewhat lighter than that of Myo5ad homozygotes (J:13058)
• coat color darkens slightly with age (J:13058)
• small spots may occur on the back, but spotting is not found on the head
• reduced foot pigmentation
• reduced tail pigmentation




Genotype
MGI:3821718
ht5
Allelic
Composition
MitfMi-wh/Mitfmi-sp
Genetic
Background
B6.Cg-MitfMi-wh/Mitfmi-sp/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-sp mutation (10 available); any Mitf mutation (57 available)
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• compound heterozygotes are pale yellow with well demarcated white spots on both the dorsum and ventrum (J:12946)
• at the first moult the hairs that had initially been pale yellow become sooty in color (J:12946)
• medullary granules vary greatly in size and shape and are less dense than wild-type
• the tail, feet, and ears are largely unpigmented although the eyes have pigment

craniofacial

hearing/vestibular/ear

limbs/digits/tail

integument
• compound heterozygotes are pale yellow with well demarcated white spots on both the dorsum and ventrum (J:12946)
• at the first moult the hairs that had initially been pale yellow become sooty in color (J:12946)
• medullary granules vary greatly in size and shape and are less dense than wild-type
• the tail, feet, and ears are largely unpigmented although the eyes have pigment

growth/size/body




Genotype
MGI:4410316
ht6
Allelic
Composition
MitfMi-b/MitfMi-wh
Genetic
Background
involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-b mutation (2 available); any Mitf mutation (57 available)
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• agouti mice are light cream with white spots
• eyes appear ruby

vision/eye
• eyes appear ruby

integument
• agouti mice are light cream with white spots




Genotype
MGI:5316609
ht7
Allelic
Composition
Mitftm5.1Arnh/MitfMi-wh
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitftm5.1Arnh mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• considerably darkened compared to heterozygous MitfMi-wh/Mitf+ mice

pigmentation
• considerably darkened compared to heterozygous MitfMi-wh/Mitf+ mice




Genotype
MGI:5316621
ht8
Allelic
Composition
Mitftm6.1Arnh/MitfMi-wh
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitftm6.1Arnh mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• slightly darker coat color

integument
• slightly darker coat color




Genotype
MGI:5316634
ht9
Allelic
Composition
Mitftm4.1Arnh/MitfMi-wh
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitftm4.1Arnh mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• gray, darkening somewhat with age
• small spots may occur on the body, but spotting is not found on the head

integument
• gray, darkening somewhat with age
• small spots may occur on the body, but spotting is not found on the head




Genotype
MGI:5316596
ht10
Allelic
Composition
Mitftm4Arnh/MitfMi-wh
Genetic
Background
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitftm4Arnh mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• fawn coat color

integument
• fawn coat color




Genotype
MGI:5316597
ht11
Allelic
Composition
Mitftm5Arnh/MitfMi-wh
Genetic
Background
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitftm5Arnh mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• fawn coat color

integument
• fawn coat color




Genotype
MGI:5316599
ht12
Allelic
Composition
Mitftm6Arnh/MitfMi-wh
Genetic
Background
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitftm6Arnh mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• fawn coat color

integument
• fawn coat color




Genotype
MGI:5316601
ht13
Allelic
Composition
Mitftm7Arnh/MitfMi-wh
Genetic
Background
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitftm7Arnh mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• fawn coat color

integument
• fawn coat color




Genotype
MGI:5316616
ht14
Allelic
Composition
Mitftm7.1Arnh/MitfMi-wh
Genetic
Background
involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitftm7.1Arnh mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• considerably darkened

integument
• considerably darkened




Genotype
MGI:2663064
ht15
Allelic
Composition
MitfMi-wh/Mitfmi-x
Genetic
Background
NZB/Mac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Mitfmi-x mutation (0 available); any Mitf mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• reduced eye size
• eyelid closure is of variable extent




Genotype
MGI:3044424
cx16
Allelic
Composition
MitfMi-wh/MitfMi-wh
Tfe3tm1Est/Tfe3tm1Est
Genetic
Background
either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Tfe3tm1Est mutation (0 available); any Tfe3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die at 3-4 weeks of age, although some survive to adulthood

pigmentation
• mice are white; similar to MitfMi-wh/Mi-wh mice

growth/size/body
• smaller and more runted than single homozygotes

skeleton
• bones show signs of osteopetrosis with intermediate extensions of bony trabeculae; less severe than in homozygous Tcfe3tm1Est mice with other Mitf mutations

vision/eye
• similar to MitfMi-wh/Mi-wh mice

integument
• mice are white; similar to MitfMi-wh/Mi-wh mice




Genotype
MGI:3044429
cx17
Allelic
Composition
MitfMi-wh/MitfMi-wh
Tfectm1Est/Tfectm1Est
Genetic
Background
either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Tfectm1Est mutation (0 available); any Tfec mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation

skeleton
N
• osteopetrosis is not observed amd bone development appears normal

vision/eye

integument




Genotype
MGI:4455023
cx18
Allelic
Composition
MitfMi-wh/MitfMi-wh
Tfe3tm1Est/Tfe3tm1Est
Tfectm1Est/Tfectm1Est
Genetic
Background
either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Tfe3tm1Est mutation (0 available); any Tfe3 mutation (19 available)
Tfectm1Est mutation (0 available); any Tfec mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation

skeleton
• mice develop osteopetrosis similar to that observed in double MitfMi-wh and Tcfe3tm1Est mutants

vision/eye

integument




Genotype
MGI:4455024
cx19
Allelic
Composition
MitfMi-wh/MitfMi-wh
Tfebtm1Est/Tfeb+
Genetic
Background
involves: 129S1/Sv * C57BL * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Tfebtm1Est mutation (0 available); any Tfeb mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation

skeleton
N
• mutants do not develop osteopetrosis

vision/eye

integument




Genotype
MGI:3762341
cx20
Allelic
Composition
MitfMi-wh/Mitf+
Myo5ad/Myo5ad
Genetic
Background
involves: C57BL * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (57 available)
Myo5ad mutation (127 available); any Myo5a mutation (203 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• coat color is pastel gray or silver
• eyes are red

vision/eye
• eyes are red

integument
• coat color is pastel gray or silver





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory