All Phenotypes Axin1<Fu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Axin1^Fu
fused
MGI:1856035

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Axin1^Fu/Axin1^Fu	Not Specified	MGI:3623257
ht2	Axin1^Fu/Axin1⁺	129P4.Cg-Axin1^Fu/J	MGI:3778021
ht3	Axin1^Fu/Axin1⁺	involves: 129/Rr * C3H/He * C57BL/6J	MGI:3778159
ht4	Axin1^Fu/Axin1⁺	involves: 129/Rr * C3H/He * C57BL/6J * wild	MGI:3778160
ht5	Axin1^Fu/Axin1⁺	involves: 129P4/RrRk * TF/Le	MGI:3778388
ht6	Axin1^Fu/Axin1⁺	involves: C57BL/6J * CBA/Lac	MGI:3777738
ht7	Axin1^Fu/Axin1⁺	involves: M. m. bactrianus	MGI:5293745
ht8	Axin1^Fu/Axin1⁺	Not Specified	MGI:3623255
cx9	A^vy/a Axin1^Fu/Axin1⁺	involves: 129P4/RrRk * C67BL/6J	MGI:3778273

Allelic Composition	Axin1^Fu/Axin1^Fu
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

circling ( J:242 )

• variable expression

craniofacial

abnormal craniofacial bone morphology ( J:242 )

• various dysmorphology can occur

• more frequent in homozygotes

digestive/alimentary system

rectal atresia ( J:12112 )

• imperforate rectum possible

hearing/vestibular/ear

deafness ( J:242 )

• seen in mouse with circling behavior

limbs/digits/tail

abnormal hindlimb morphology ( J:12953 )

• reduction in hind leg may occur

• more frequent in homozygote

abnormal tail morphology ( J:67881 )

• mitotic gene conversion events during early development produce mosaicism, an explanation for variable tail phenotype expression

abnormal caudal vertebrae morphology ( J:12953 )

decreased caudal vertebrae number ( J:12953 )

short tail ( J:12953 )

• homozygotes are likely to have shorter tails than heterozygotes

bifurcated tail ( J:12953 )

• homozygotes are more likely to have bifurcated tails than heterozygotes

renal/urinary system

abnormal kidney development ( J:12112 )

absent kidney ( J:12953 )

• one or both kidneys and ureters may be missing

absent ureter ( J:12953 )

• one or both kidneys and ureters may be missing

urethra atresia ( J:12112 )

• imperforate urethra possible

skeleton

abnormal axial skeleton morphology ( J:12953 )

abnormal craniofacial bone morphology ( J:242 )

• various dysmorphology can occur

• more frequent in homozygotes

absent ribs ( J:12953 )

• number absent and frequency of absence is variable

rib fusion ( J:12953 )

• number of ribs fused and location are variable

abnormal vertebrae morphology ( J:12953 )

abnormal caudal vertebrae morphology ( J:12953 )

decreased caudal vertebrae number ( J:12953 )

cellular

maternal effect ( J:12953 )

• offspring of homozygous or heterozygous Axin1^Fu mothers are less likely to express abnormalities than offspring of homozygous wild-type mothers

Allelic Composition	Axin1^Fu/Axin1⁺
Genetic Background	129P4.Cg-Axin1^Fu/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

genetic imprinting ( J:82396 )

• severity of phenotype is transmitted, particularly through males

maternal imprinting ( J:82396 )

• penetrant heterozygous dams transmit 46% penetrant and 54% silent offspring and non-penetrant heterozygous dams transmit 30% penetrant and 70% silent offspring

paternal imprinting ( J:82396 )

• penetrant heterozygous sires transmit 76% penetrant offspring while non-penetrant heterozygous sires transmit only 60% penetrant offspring.

• the LTR/intron 6 region is heavily methylated in non-penetrant heterozygotes and relatively hypomethylated in penetrant heterozygotes

Allelic Composition	Axin1^Fu/Axin1⁺
Genetic Background	involves: 129/Rr * C3H/He * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

genetic imprinting ( J:6577 )

• penetrance is reduced when transmitted from males, rather than females, when the fused carrier parent is of a mixed 129/Rr and C3H/He background and the non-carrier parent is a tufted homozygote on the C57BL/6J background

paternal imprinting ( J:6577 )

Allelic Composition	Axin1^Fu/Axin1⁺
Genetic Background	involves: 129/Rr * C3H/He * C57BL/6J * wild

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

genetic imprinting ( J:6577 )

• Background Sensitivity: a homozygote on a mixed background transmits lower penetrance of fused when bred to a wild mouse from the environs of Novosibirsk than when bred to a C3H mouse

Allelic Composition	Axin1^Fu/Axin1⁺
Genetic Background	involves: 129P4/RrRk * TF/Le

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

reversion by viral sequence excision ( J:68896 )

• many instances of non-expression of the fused phenotype are not due to redueced penetrance but rather to spontaneous viral excision

Allelic Composition	Axin1^Fu/Axin1⁺
Genetic Background	involves: C57BL/6J * CBA/Lac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

paternal imprinting ( J:133043 )

• Penetrance of the fused phenotype is decreased when transmitted from males injected with hydrocortisone acetate prior to breeding.

Allelic Composition	Axin1^Fu/Axin1⁺
Genetic Background	involves: M. m. bactrianus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:12953 )

• dominant skeletal abnormalities are not observed in mice of this genotype and background

Allelic Composition	Axin1^Fu/Axin1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:12953 )

abnormal craniofacial bone morphology ( J:12112 )

• various dysmorphology can occur

absent ribs ( J:12953 )

• number absent and frequency of absence is variable

rib fusion ( J:12953 )

• number of ribs fused and location are variable

abnormal vertebrae morphology ( J:12953 )

abnormal caudal vertebrae morphology ( J:12953 )

decreased caudal vertebrae number ( J:12953 )

limbs/digits/tail

abnormal hindlimb morphology ( J:12953 )

• reduction in hind leg may occur

abnormal caudal vertebrae morphology ( J:12953 )

decreased caudal vertebrae number ( J:12953 )

abnormal tail length ( J:12953 )

• tail length may be variable

bifurcated tail ( J:12953 )

• bifurcated tail is seen infrequently

behavior/neurological

circling ( J:242 )

• variable expression

hearing/vestibular/ear

deafness ( J:242 )

• associated with circling behavior

craniofacial

abnormal craniofacial bone morphology ( J:12112 )

• various dysmorphology can occur

renal/urinary system

abnormal kidney development ( J:12112 )

absent kidney ( J:12112 )

• one or both kidneys and ureters may be missing

urethra atresia ( J:12112 )

• imperforate urethra possible

digestive/alimentary system

rectal atresia ( J:12112 )

• imperforate rectum possible

cellular

maternal effect ( J:12953 )

• offspring of heterozygous and homozygous Axin1^Fu mothers are less likely to express abnormalities than offspring of homozygous wild-type mothers

Allelic Composition	A^vy/a Axin1^Fu/Axin1⁺
Genetic Background	involves: 129P4/RrRk * C67BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

genetic imprinting ( J:82396 )

• penetrance of fused and viable yellow are independent of each other with double heterozygotes displaying all combinations of coat color and tail phenotypes due to independent variations in penetrance of each

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