Tg(H2-K-GPX1,-SOD1,-SOD3*)CCpj
Transgene Detail

Summary

• Symbol: Tg(H2-K-GPX1,-SOD1,-SOD3*)CCpj
• Name: transgene insertion C, Peter J Cowan
• MGI ID: MGI:7569319
• Synonyms: SOD1.SOD3.Gpx1.Tg, Tg(H2-K-GPX1,-SOD1,-SOD3/CD55)CCpj
• Transgene: Tg(H2-K-GPX1,-SOD1,-SOD3*)CCpj Location: unknown
• Alliance: Tg(H2-K-GPX1,-SOD1,-SOD3*)CCpj page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K-GPX1,-SOD1,-SOD3*)CCpj expresses 3 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GPX1 (2876)

  Gpx1	(MGI:104887)

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

  human

  SOD3 (6649)

  Sod3	(MGI:103181)

• Tg(H2-K-GPX1,-SOD1,-SOD3*)CCpj expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	H2-K (MGI:3040519)

• Mutation details: Co-injection integrated three transgenes that express from the mouse H-2Kb (MHC Class I) promoter: 1) human CuZn superoxide dismutase (SOD1) tagged with a hemagglutinin epitope tag; 2) human extracellular superoxide dismutase (SOD3) modified to include a glycosyl phosphatidylinositol (GPI) membrane linkage signal & tagged with a FLAG epitope tag; 3) human cellular glutathione peroxidase (Gpx-1) tagged with a histidine (6xHis) tag. (J:100091)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:100091 Mysore TB, et al., Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function. Diabetes. 2005 Jul;54(7):2109-16
• All: 1 reference(s)