H2-K Complex/Cluster/Region Detail

Summary

• Symbol
  H2-K
• Name
  histocompatibility 2, K region

• Feature Type
  complex/cluster/region
• IDs
  MGI:3040519
• Candidate for QTL
  1 QTL

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, Syntenic
• Mapping Data
  5 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 4 alleles in 3 genetic backgrounds
  1 phenotype from multigenic genotypes
  152 phenotype references
  

• All Mutations and Alleles
  18
• Spontaneous
  12
• Transgenic
  6
• Find Mice (IMSR)
  31 strains or lines available

Expression

• Assay Results
  2
• Tissues
  1
• Literature Summary
  1

Tissue x Stage Matrix

References

• Summaries
  All 178

  Developmental Gene Expression 1

  Phenotypes 152
• Earliest
  J:268922 Bailey DW, et al., Inherited histocompatibility changes in progeny of irradiated and unirradiated inbred mice. Genet Res Camb. 1965;6:330-340
• Latest
  J:346655 Ashayeripanah M, et al., Systemic inflammatory response syndrome triggered by blood-borne pathogens induces prolonged dendritic cell paralysis and immunosuppression. Cell Rep. 2024 Feb 27;43(2):113754

H2-K is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Blmpf1	Chr17, 17.25 cM	Chr17:32061652-37644775	J:100369	Gene expression analysis was used to identify candidate genes for bleomycin-induced pulmonary fibrorsis QTLs Blmpf1 and Blmpf2. These loci were previously mapped in an F2 cross between susceptible strain C57BL/6J and resistant strain C3Hf/Kam. Blmpf1 maps to 17.4 cM on mouse Chromosome 17 and Blmpf2 maps to 28 cM on mouse Chromosome 11. Genes mapping to the Blmpf1 interval on mouse Chromosome 17 were evaluated for lung mRNA expression in C57BL/6J and C3Hf/Kam animals with and without bleomycin treatment. Genes showing significant expression differences with P<0.001 are H2-D1 (19.09 cM), C4 (18.8 cM), Glo1 (16 cM), H2-Q7 (19.19 cM), H2-K (18.65 cM), Gabbr1 (20.4 cM), Tff2 (17 cM), Notch4 (18.72 cM), and Fkbp5 (13 cM). Genes mapping to the Blmpf2 interval on mouse Chromosome 11 were evaluated for lung mRNA expression in C57BL/6J and C3Hf/Kam animals with and without bleomycin treatment. Genes showing significant expression differences with P<0.001 are Scgb3a1 (25 cM), Trim16, Pttg1, and Gria1 (31 cM).

*cM position of peak correlated region/marker