Del(4Cdkn2a-Cdkn2b)3Nki
Targeted Allele Detail

Summary

• Symbol: Del(4Cdkn2a-Cdkn2b)3Nki
• Name: deletion, Chr 4, The Netherlands Cancer Institute 3
• MGI ID: MGI:7447431
• Gene: Del(4Cdkn2a-Cdkn2b)3Nki Location: unknown Genetic Position: Chr3, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273283
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Recombination between Cdkn2a^tm3Nki and Cdkn2b^tm3Nki removes the coding sequence of Cdkn2b through exons 1 beta of Cdkn2a. (J:273283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(4Cdkn2a-Cdkn2b)3Nki Mutation: 0 strains or lines available

References

• Original: J:273283 Krimpenfort P, et al., A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis. Nat Commun. 2019 Mar 29;10(1):1425
• All: 1 reference(s)