Wwc2^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Wwc2^tm1.1Arte
• Name: WW, C2 and coiled-coil domain containing 2; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6711442
• Synonyms: WWC2^fl
• Gene: Wwc2 Location: Chr8:48279117-48443579 bp, - strand Genetic Position: Chr8, 26.91 cM
• Alliance: Wwc2^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305034
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT-flanked neomycin resistance cassette were inserted upstream of exon 2 and an F3-flanked puromycin resistance cassette and second loxP site were inserted downstream of exon 2. Flp-mediated recombination removed the selection cassettes, leaving exon 2 floxed. (J:305034)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwc2 Mutation: 70 strains or lines available

References

• Original: J:305034 Hermann A, et al., WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway. Hepatology. 2018 Apr;67(4):1546-1559
• All: 3 reference(s)