Irag2^rs13459098-C
Allele Detail

Summary

• Symbol: Irag2^rs13459098-C
• Name: inositol 1,4,5-triphosphate receptor associated 2; rs13459098 SNP allele with the C variant
• MGI ID: MGI:6285971
• Gene: Irag2 Location: Chr6:145061379-145120660 bp, + strand Genetic Position: Chr6, 77.34 cM
• Alliance: Irag2^rs13459098-C page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Not Applicable (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: This C variant of the SNP is found in the last exon of the gene in the pulmonary adenoma susceptibility 1 (Pas1) region in the SM/J, LP/J, CBA/J, PL/J, 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, ST/bJ, BALB/cJ, RIIIS/J, MA/MyJ, O20, SWR/J, FVB/NJ, NOD/ShiLtJ, SPRET/EiJ, WSB/EiJ, and A/J strains and creates a proline codon (CCG) at position 537 (UniProt G5E880) that confers susceptibility to urethane-induced pulmonary adenomas. This sensitivity is modulated by epistatic interactions with the 4930503L19Rik^rs29775155-C, 4930503L19Rik^{rs216509331-G}, 4930503L19Rik^{rs216509331-A}, 4930503L19Rik^rs30245983-A, 4930503L19Rik^{rs241863237-ins}, 4930503L19Rik^rs30066196-T, and 4930503L19Rik^{rs222904565-del} sensitive alleles and the 4930503L19Rik^rs29775155-A, 4930503L19Rik^{rs216509331-T}, 4930503L19Rik^rs30066196-C, 4930503L19Rik^{rs222904565-ins}, 4930503L19Rik^rs30245983-G, and 4930503L19Rik^{rs241863237-del} resistant alleles in the Par2 (pulmonary adenoma resistance 2) region. (J:150946)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irag2 Mutation: 44 strains or lines available

References

• Original: J:150946 Liu PY, et al., Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Cancer Res. 2009 Aug 1;69(15):6290-8
• All: 1 reference(s)