4930503L19Rik^{rs222904565-del}
Allele Detail

Summary

• Symbol: 4930503L19Rik^{rs222904565-del}
• Name: RIKEN cDNA 4930503L19 gene; rs222904565 SV allele with the deletion variant
• MGI ID: MGI:6285653
• Gene: 4930503L19Rik Location: Chr18:70585283-70605580 bp, - strand Genetic Position: Chr18, 44.42 cM
• Alliance: 4930503L19Rik^{rs222904565-del} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Not Applicable
• Mutation: Undefined
• Mutation details: The SJL/J, NZB/BINJ, C57BL/10J, C57BL/6J, RIIIS/J, MA/MyJ, SWR/J and A/J strains carry this allele. The molecular difference with other strains is the deletion of three base pairs (TTC) in the coding region of exon 4. This deletes a lysine between glutamic acid 235 and asparagine 236 in the encoded protein (UniProt Q8CB14), that confers resistance to urethane-induced pulmonary adenomas. This allele co-occurs with the 4930503L19Rik^rs30066196-T, 4930503L19Rik^{rs216509331-G}, 4930503L19Rik^rs29775155-C, 4930503L19Rik^rs30245983-A, and 4930503L19Rik^{rs241863237-ins} alleles to confer sensitivity. Through epistatic interaction with the Lrmp^rs13459098-C sensitive and Lrmp^rs13459098-T resistant alleles in the pulmonary adenoma susceptibility 1 (Pas1) region these Par2 alleles modulate the sensitivity or resistance of the two Pas1 alleles. (J:150946)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any 4930503L19Rik Mutation: 18 strains or lines available

References

• Original: J:150946 Liu PY, et al., Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Cancer Res. 2009 Aug 1;69(15):6290-8
• All: 1 reference(s)