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Ccr5tm1(CCR5)Pfi
Targeted Allele Detail
Nomenclature
Symbol: Ccr5tm1(CCR5)Pfi
Name: chemokine (C-C motif) receptor 5; targeted mutation 1, Pfizer, Ltd
MGI ID: MGI:5774771
Synonyms: h-CCR5 ki
Gene: Ccr5  Location: Chr9:124121543-124127183 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227458
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutation:    Intragenic deletion
 
Ccr5tm1(CCR5)Pfi expresses 1 gene
    The murine Ccr5 is replaced by human CCR5. (J:227458)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccr5 Mutation:  23 strains or lines available
References
Original:  J:227458 Amsellem V, et al., CCR5 as a treatment target in pulmonary arterial hypertension. Circulation. 2014 Sep 9;130(11):880-891
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory