All Phenotypes Ccr5<tm1(CCR5)Pfi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccr5^tm1(CCR5)Pfi
targeted mutation 1, Pfizer, Ltd
MGI:5774771

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccr5^tm1(CCR5)Pfi/Ccr5^tm1(CCR5)Pfi	involves: C57BL/6	MGI:5774772

Allelic Composition	Ccr5^tm1(CCR5)Pfi/Ccr5^tm1(CCR5)Pfi
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr5^tm1(CCR5)Pfi mutation (0 available); any Ccr5 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:227458 )

N	• mice develop a similar severity of pulmonary hypertension as wild-type mice after 18 days of hypoxia

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:227458 )

• treatment with Maraviroc 200 attenuates but does not fully abrogate hypoxia-induced pulmonary hypertension development in mutants compared to having no effect in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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