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Faslm2Btlr
Chemically induced Allele Detail
Nomenclature
Symbol: Faslm2Btlr
Name: Fas ligand (TNF superfamily, member 6); mutation 2, Bruce Beutler
MGI ID: MGI:5688496
Synonyms: riogrande2
Gene: Fasl  Location: Chr1:161780691-161788495 bp, - strand  Genetic Position: Chr1, 69.95 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced an A to C transversion at base pair 161,787,138 (v38) on chromosome 1, or base pair 8,401 in the GenBank genomic region NC_000067. The mutation corresponds to residue 565 in the mRNA sequence NM_010177 within exon 2 of 4 total exons. The mutation results in a serine (S) to arginine (R) substitution at position 119 (S119R) in the protein. (J:224659)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:  26 strains or lines available
References
Original:  J:224659 Wang KW, et al., Mutagenetix entry for riogrande2. MGI Direct Data Submission. 2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory