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Mirc1tm3.1Aven
Targeted Allele Detail
Nomenclature
Symbol: Mirc1tm3.1Aven
Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 3.1, Andrea Ventura
MGI ID: MGI:5648471
Synonyms: miR-17~92 delta17,18
Gene: Mirc1  Location: Chr14:115043671-115044506 bp  Genetic Position: Chr14, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223213
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
  Mirc1tm3.1Aven involves 3 genes/genome features (Mir17, Mir18, Mir20a) View all
 
Mutation detailsThe Mir17, Mir18 and Mir20a genes were replaced by an FRT-flanked neomycin cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:223213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mirc1 Mutation:  6 strains or lines available
References
Original:  J:223213 Han YC, et al., An allelic series of miR-17 approximately 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jul;47(7):766-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory