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Transgene Detail
Symbol: Tg(HLA-DRA,HLA-DRB5*0101)loKito
Name: transgene insertion lo, Kouichi Ito
MGI ID: MGI:5635431
Synonyms: DR2alo
Transgene: Tg(HLA-DRA,HLA-DRB5*0101)loKito  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(HLA-DRA,HLA-DRB5*0101)loKito expresses 4 genes
Mutation detailsA chimeric MHC class II complex was created by fusing the human peptide antigen binding domains of class II alpha and beta chains (HLA-DRA and HLA-DRB5*01:01) to the remaining domains of murine class II alpha or beta chains (H2-Ea-ps and H2-Eb1 genes that make up mouse I-Ed). The chimeric gene constructs were manipulated by replacing exon 2 of IEd-alpha or IEd-beta genomic DNA with gene fragments containing exon 2 of HLA-DRA or HLA-DRB5*01:01, respectively. The native murine promoters were left intact. Two lines were created, a high expressing line (hi) and a low expressing line (lo). (J:189816)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:189816 Quandt JA, et al., Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis. J Immunol. 2012 Sep 15;189(6):2897-908
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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