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Mir10atm1.1Ahl
Targeted Allele Detail
Nomenclature
Symbol: Mir10atm1.1Ahl
Name: microRNA 10a; targeted mutation 1.1, Anders Lund
MGI ID: MGI:5567937
Gene: Mir10a  Location: Chr11:96317165-96317274 bp, + strand  Genetic Position: Chr11, 59.83 cM
Enhanced intestinal tumorigenesis in ApcMin/Apc+ Mir10atm1.1Ahl/Mir10atm1.1Ahl mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205135
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced the central 70 bp. Cre-mediated recombination removed the selection cassette. (J:205135)
Generation of the Mir10atm1.1Ahl allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mir10a Mutation:  2 strains or lines available
References
Original:  J:205135 Stadthagen G, et al., Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice. PLoS Genet. 2013 Oct;9(10):e1003913
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory