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Targeted Allele Detail
Symbol: Mir10atm1.1Ahl
Name: microRNA 10a; targeted mutation 1.1, Anders Lund
MGI ID: MGI:5567937
Gene: Mir10a  Location: Chr11:96317165-96317274 bp, + strand  Genetic Position: Chr11, 59.83 cM
Enhanced intestinal tumorigenesis in ApcMin/Apc+ Mir10atm1.1Ahl/Mir10atm1.1Ahl mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:205135
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed neomycin resistance cassette replaced the central 70 bp. Cre-mediated recombination removed the selection cassette. (J:205135)
Generation of the Mir10atm1.1Ahl allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mir10a Mutation:  2 strains or lines available
Original:  J:205135 Stadthagen G, et al., Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice. PLoS Genet. 2013 Oct;9(10):e1003913
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory