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Wwtr1tm1.1Eno
Targeted Allele Detail
Summary
Symbol: Wwtr1tm1.1Eno
Name: WW domain containing transcription regulator 1; targeted mutation 1.1, Eric N Olson
MGI ID: MGI:5544289
Synonyms: Tazfl, TazloxP
Gene: Wwtr1  Location: Chr3:57363070-57483331 bp, - strand  Genetic Position: Chr3, 27.74 cM
Alliance: Wwtr1tm1.1Eno page
Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200670
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3. Flp mediated recombination removed the neo cassette. (J:200670)
Generation of the Wwtr1tm1.1Eno and Wwtr1tm1.2Eno alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wwtr1 Mutation:  23 strains or lines available
References
Original:  J:200670 Xin M, et al., Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44
All:  78 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory