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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wwtr1tm1.1Eno
targeted mutation 1.1, Eric N Olson
MGI:5544289
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wwtr1tm1.1Eno/Wwtr1+
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0 		involves: 129S/SvEv * FVB/N MGI:5544297
cn2
 		Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Tg(Myh6-cre)2182Mds/0 		involves: 129S/SvEv * FVB/N MGI:5544299
cn3
 		Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0 		involves: 129S/SvEv * FVB/N MGI:5544298
cn4
 		Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1+
Tg(Myh6-cre)2182Mds/0 		involves: 129S/SvEv * FVB/N MGI:5544296


Genotype
MGI:5544297
cn1
Allelic
Composition		 Wwtr1tm1.1Eno/Wwtr1+
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S/SvEv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Wwtr1tm1.1Eno mutation (0 available); any Wwtr1 mutation (23 available)
Yap1tm1.1Eno mutation (0 available); any Yap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

mortality/aging
postnatal lethality, complete penetrance ( J:200670 )
• die by 10 days of age
• lethality is accelerated compared to mutant mice wild type for Wwtr1

cardiovascular system
myocardium hypoplasia ( J:200670 )
• about a 60% decrease in the number of cardiomyocytes

cellular

muscle
myocardium hypoplasia ( J:200670 )
• about a 60% decrease in the number of cardiomyocytes




Genotype
MGI:5544299
cn2
Allelic
Composition		 Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S/SvEv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Wwtr1tm1.1Eno mutation (0 available); any Wwtr1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:200670 )
N
• no obvious cardiac defects




Genotype
MGI:5544298
cn3
Allelic
Composition		 Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S/SvEv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Wwtr1tm1.1Eno mutation (0 available); any Wwtr1 mutation (23 available)
Yap1tm1.1Eno mutation (0 available); any Yap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Wwtr1tm1.1Eno/Wwtr1tm1.1Eno Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice exhibit cardiac abnormalities and Wwtr1tm1.1Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 hearts show defects in proliferation and survival

mortality/aging

cardiovascular system
abnormal heart morphology ( J:200670 )
• severe cardiac defects




Genotype
MGI:5544296
cn4
Allelic
Composition		 Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1+
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S/SvEv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Wwtr1tm1.1Eno mutation (0 available); any Wwtr1 mutation (23 available)
Yap1tm1.1Eno mutation (0 available); any Yap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1tm1.2Eno Yap1tm1.1Eno/Yap1+ Tg(Myh6-cre)2182Mds/0 mice

mortality/aging
premature death ( J:200670 )
• complete lethality by 33 weeks of age from heart failure

cardiovascular system
dilated cardiomyopathy ( J:200670 )
• grossly dilated at 30 weeks of age but seen as early as 8 days of age

homeostasis/metabolism
abnormal atrial thrombosis ( J:200670 )
• at 30 weeks of age

muscle
dilated cardiomyopathy ( J:200670 )
• grossly dilated at 30 weeks of age but seen as early as 8 days of age




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory