Tg(Guca1a*L151F/EGFP)#Wbae
Transgene Detail

Summary

• Symbol: Tg(Guca1a*L151F/EGFP)#Wbae
• Name: transgene insertion, Wolfgang Baehr
• MGI ID: MGI:5523963
• Synonyms: G1(L151F)-GFP
• Transgene: Tg(Guca1a*L151F/EGFP)#Wbae Location: unknown
• Alliance: Tg(Guca1a*L151F/EGFP)#Wbae page

Slowly progressive photoreceptor degeneration in Tg(Guca1a*L151F/EGFP)#Wbae/0 and Tg(Guca1a*L151F)#Wbae/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Guca1a*L151F/EGFP)#Wbae expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Guca1a (MGI:102770)

• Mutation details: This transgene expresses mouse Guca1a with a C to T point mutation in codon 151 (L151F) fused to a C-terminal EGFP under the control of endogenous regulatory elements. Expression is localized to the photoreceptor inner and outer segments. One line was created and the pound symbol (#) is used when the line is not specified. (J:199392)

Schematic of the Tg(Guca1a*L151F)#Wbae and Tg(Guca1a*L151F/EGFP)#Wbae transgenes

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:199392 Jiang L, et al., RNAi-mediated gene suppression in a GCAP1(L151F) cone-rod dystrophy mouse model. PLoS One. 2013;8(3):e57676
• All: 1 reference(s)