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| Caption | Schematic of the Tg(Guca1a*L151F)#Wbae (G1(L151F)) and Tg(Guca1a*L151F/EGFP)#Wbae (G1(L151F)-EGFP) transgenes. Schematic of three mouse GCAP1 genomic transgene constructs: (G1(L151F) (A), G1(L151F)-GFP (B) and G1-GFP (C). Black boxes depict exons 1-4. Tsp, transcription start point; ATG and TAA, translation start and stop codons; pA, polyadenylation signal. All transgenes contain the entire Guca1a genomic sequence, including 6.2 kb promoter and 2.5 kb 3'-UTR sequence. Oligonucleotide pair (horizontal arrows, A), G1F and G1R, were used for genotyping. The C45I1 point mutation was introduced at exon 4 (red stars) resulting in a L151F mutation of G1(L151F) and G1(L151F)-GFP transgenes. In transgenes G1(L151F)-GFP and G1-GFP, EGFP was inserted immediately upstream of the stop codon. | ||||||
| Copyright | This image is from Jiang L, PLoS One 2013;8(3):e57676, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199392 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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