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| Caption | Slowly progressive photoreceptor degeneration in Tg(Guca1a*L151F/EGFP)#Wbae/0 (G1(L151F)-GFP) and Tg(Guca1a*L151F)#Wbae/0 (G1(L151F)) mice. Retinal morphology of the three transgenic lines and age-matched controls were analyzed with plastic retinal sections at ages 2, 9 and 12 months (A). Retinas from G1(L151F) and G1(L151F)-GFP mutant transgenic mice show no morphological change at age 2 months (top, left two panels) compared to control retinas (top, right two panels). At 9 months of age, a thinned photoreceptor layer (including OS, IS and ONL) becomes evident with about 10% reduction (middle, left two panels). Photoreceptor layer thinning became more obvious at 12 months with about 20-30% reduction (bottom, left two panels). In contrast, G1-GFP and age-matched wild-type photoreceptor layers are normal at all three ages (bottom, right two panels). Abbreviations: OS, outer segment; IS, inner segment; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, the inner nuclear layer. B. Quantitation of the photoreceptor outer nuclear layer (ONL) thickness in three transgenic mice and age-matched controls at 12 months of age. ONL thickness was measured every 250 um moving from the optic nerve head (ONH) to the periphery, both inferiorly and superiorly. ONL thickness was reduced in retinas of G1(L151F) and G1(L151F)-GFP transgenic mice, but not in G1-GFP transgenic or wild-type mice. (n=3 each group). | ||||||
| Copyright | This image is from Jiang L, PLoS One 2013;8(3):e57676, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199392 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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