Tg(Guca1a*L151F)#Wbae
Transgene Detail

Summary

• Symbol: Tg(Guca1a*L151F)#Wbae
• Name: transgene insertion, Wolfgang Baehr
• MGI ID: MGI:5523961
• Synonyms: G1(L151F)
• Transgene: Tg(Guca1a*L151F)#Wbae Location: unknown
• Alliance: Tg(Guca1a*L151F)#Wbae page

Slowly progressive photoreceptor degeneration in Tg(Guca1a*L151F/EGFP)#Wbae/0 and Tg(Guca1a*L151F)#Wbae/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Guca1a*L151F)#Wbae expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Guca1a (MGI:102770)

• Mutation details: This transgene expresses mouse Guca1a with a C to T point mutation in codon 151 (L151F) under the control of endogenous regulatory elements. Expression is localized to the photoreceptor inner and outer segments, with stronger expression in the cones than rods. One line was created and the pound symbol (#) is used when the line is not specified. (J:199392)

Schematic of the Tg(Guca1a*L151F)#Wbae and Tg(Guca1a*L151F/EGFP)#Wbae transgenes

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:199392 Jiang L, et al., RNAi-mediated gene suppression in a GCAP1(L151F) cone-rod dystrophy mouse model. PLoS One. 2013;8(3):e57676
• All: 1 reference(s)