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Cdc42tm1.1Rac
Targeted Allele Detail
Nomenclature
Symbol: Cdc42tm1.1Rac
Name: cell division cycle 42; targeted mutation 1.1, Richard A Cerione
MGI ID: MGI:5495277
Synonyms: Cdc42flox
Gene: Cdc42  Location: Chr4:137319696-137357720 bp, - strand  Genetic Position: Chr4, 69.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197886
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exon 2 was floxed. Cre-mediated recombination removed the floxed neo cassette. (J:197886)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc42 Mutation:  36 strains or lines available
References
Original:  J:197886 Peng X, et al., Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein Cell. 2013 Mar;4(3):231-42
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory