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Panx1tm1.1Vshe
Targeted Allele Detail
Nomenclature
Symbol: Panx1tm1.1Vshe
Name: pannexin 1; targeted mutation 1.1, Valery I Shestopalov
MGI ID: MGI:5487761
Gene: Panx1  Location: Chr9:15005785-15045478 bp, - strand  Genetic Position: Chr9, 4.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196355
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the neo cassette and exons 3 and 4. Western blot analysis confirmed the absence of protein expression in the brain and retina. (J:196355)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Panx1 Mutation:  4 strains or lines available
References
Original:  J:196355 Dvoriantchikova G, et al., Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. PLoS One. 2012;7(2):e31991
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory