Phenotypes associated with this allele

• Allele Symbol: Panx1^tm1.1Vshe
• Allele Name: targeted mutation 1.1, Valery I Shestopalov
• Allele ID: MGI:5487761
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Panx1^tm1.1Vshe/Panx1^tm1.1Vshe	B6.129-Panx1^tm1.1Vshe	MGI:5488660

Genotype
MGI:5488660

hm1

• Allelic Composition: Panx1^tm1.1Vshe/Panx1^tm1.1Vshe
• Genetic Background: B6.129-Panx1^tm1.1Vshe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neuron apoptosis ( J:196355 )

• following ischemia/reperfusion injury

increased retina ganglion cell number ( J:196355 )

• following ischemia/reperfusion injury

homeostasis/metabolism

abnormal response to injury ( J:196355 )

• following ischemia/reperfusion injury, retina exhibit reduced retinal ganglion cell (RGC) loss and increased RGC and neuronal survival with less apoptosis compared with wild-type mice

• following oxygen and glucose deprivation, retinal ganglion cells exhibit reduced permeation compared with wild-type cells

vision/eye

increased retina ganglion cell number ( J:196355 )

• following ischemia/reperfusion injury

cellular

decreased neuron apoptosis ( J:196355 )

• following ischemia/reperfusion injury