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Cdcp1tm1.2Moas
Targeted Allele Detail
Nomenclature
Symbol: Cdcp1tm1.2Moas
Name: CUB domain containing protein 1; targeted mutation 1.2, Mark Moasser
MGI ID: MGI:5442763
Gene: Cdcp1  Location: Chr9:123170824-123216038 bp, - strand  Genetic Position: Chr9, 73.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194368
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing a FRT site-flanked NEO cassette was utilized in the construction of this mutant. A loxP site and the selection cassette were inserted downstream of exon 1 of the targeted gene, and another loxP site was inserted upstream of exon 1. Flp-mediated recombination removed the neo cassette and cre-mediated recombination removed exon 1. No gene product (protein) is detected by Western blot analysis of skin and intestine from homozygous mice. (J:194368)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdcp1 Mutation:  26 strains or lines available
References
Original:  J:194368 Spassov DS, et al., Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. Cancer Res. 2013 Feb 1;73(3):1168-79
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory