Tgm3^tm1Sjo
Targeted Allele Detail

Summary

• Symbol: Tgm3^tm1Sjo
• Name: transglutaminase 3, E polypeptide; targeted mutation 1, Susan John
• MGI ID: MGI:5436399
• Gene: Tgm3 Location: Chr2:129854269-129892319 bp, + strand Genetic Position: Chr2, 63.19 cM
• Alliance: Tgm3^tm1Sjo page

Wavy hair and irregular vibrissae in Tgm3^tm1Sjo/Tgm3^tm1Sjo mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187109
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: Insertion of a neo cassette via homologous recombination disrupted exon 6. RT-PCR and western blot analysis confirmed the absence of mRNA and protein expression in tissues from homozygous mice. (J:187109)

Generation of the Tgm3^tm1Sjo allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgm3 Mutation: 53 strains or lines available

References

• Original: J:187109 John S, et al., Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier. PLoS One. 2012;7(4):e34252
• All: 2 reference(s)