Aatk^tm1Shhi
Targeted Allele Detail

Summary

• Symbol: Aatk^tm1Shhi
• Name: apoptosis-associated tyrosine kinase; targeted mutation 1, Shin-ichi Hisanaga
• MGI ID: MGI:5428170
• Gene: Aatk Location: Chr11:119898139-119937993 bp, - strand Genetic Position: Chr11, 83.96 cM, cytoband E2
• Alliance: Aatk^tm1Shhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184851
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exons 4 through 7. Western blot analysis confirmed the absence of protein expression in cortical neurons. (J:184851)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aatk Mutation: 61 strains or lines available

References

• Original: J:184851 Takano T, et al., LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. J Neurosci. 2012 May 9;32(19):6587-99
• All: 4 reference(s)